INT133211

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 169
Total Number 205
Disease Relevance 83.40
Pain Relevance 76.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
neurons 54
nociceptors 26
embryos 8
ganglia 7
neuronal 6
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 4833 100.00 Very High Very High Very High
dorsal root ganglion 2514 100.00 Very High Very High Very High
Spinal cord 828 99.96 Very High Very High Very High
Central nervous system 237 99.96 Very High Very High Very High
Neuropathic pain 1726 99.92 Very High Very High Very High
trigeminal ganglion 2505 99.72 Very High Very High Very High
medulla 440 99.68 Very High Very High Very High
midbrain 37 99.64 Very High Very High Very High
Peripheral nervous system 225 99.52 Very High Very High Very High
calcitonin gene related peptide 363 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5409 100.00 Very High Very High Very High
Targeted Disruption 2945 100.00 Very High Very High Very High
Nociception 933 100.00 Very High Very High Very High
Myeloid Leukemia 748 100.00 Very High Very High Very High
Neuropathic Pain 2141 99.92 Very High Very High Very High
Neurodegenerative Disease 309 99.60 Very High Very High Very High
Injury 288 99.52 Very High Very High Very High
Repression 378 99.44 Very High Very High Very High
Pain 1086 99.20 Very High Very High Very High
Hypersensitivity 352 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Runx1 expression in these cells is first observed at approximately gestational day 12.5, persists into the adult brain, and is lost in knockout mice lacking the transcription factor Atoh1, an important regulator of the development of neuronal lineages of the rhombic lip.
Gene_expression (expression) of Runx1 in neuronal associated with targeted disruption
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0.10 Pain Relevance 0.19
In agreement with previous studies [16], Runx1 expression was also observed in the vestibulocochlear ganglia of Atoh1+/+ (Fig. 6A5) and Atoh1+/– (Fig. 6B5) embryos.
Gene_expression (expression) of Runx1 in ganglia
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.24
The analysis of Runx1 expression in neuronal cells other than specific subpopulations of sensory and motor neurons remains incomplete.
Gene_expression (expression) of Runx1 in neuronal
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.37
Here we provide evidence that Runx1 expression defines a population of post-mitotic neurons located in a dorsolateral position of the rostral hindbrain.
Gene_expression (expression) of Runx1 in hindbrain
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.05 Pain Relevance 0.40
The finding that Runx1 is expressed in neurons of the LPBS presents a possibility that Runx1 could also play a role in certain integrated functional systems.
Gene_expression (expressed) of Runx1 in neurons
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.09 Pain Relevance 0.18
Anatomical and immunohistochemical studies were used to characterize mouse Runx1 expression in the brainstem.
Gene_expression (expression) of Runx1 in brainstem associated with medulla
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0.06 Pain Relevance 0.17
Loss of Runx1 expression in neurons of the superior lateral parabrachial nucleus in Atoh1-deficient mice
Gene_expression (expression) of Runx1 in lateral associated with parabrachial
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.32
In the developing murine olfactory epithelium, Runx1 is expressed in mitotic olfactory sensory neuron precursors where it is involved in promoting proliferation [7].
Gene_expression (expressed) of Runx1 in olfactory sensory neuron
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.24
To determine whether Runx1-expressing neurons of the LPBS are derived from Atoh1-expressing progenitors, we compared the expression of the Runx1 protein in E14.5 Atoh1–/– embryos and their Atoh1+/+ and Atoh1+/– littermates [29].
Gene_expression (expression) of Runx1 in embryos
9) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.22
Similarly, Runx1 is expressed within the PNS in particular populations of postmitotic trigeminal, vestibular and DRG sensory neurons [8]–[11], [16].
Gene_expression (expressed) of Runx1 in PNS associated with peripheral nervous system
10) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.39
In other neuronal lineages investigated to date, Runx1 is expressed exclusively in post-mitotic neurons and plays important roles in phenotype specification and axonal targeting.
Gene_expression (expressed) of Runx1 in neurons
11) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.28
Runx1 is expressed in nociceptors of DRG [49] and trigeminal ganglia [16].
Gene_expression (expressed) of Runx1 in trigeminal ganglia associated with nociceptor
12) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.64 Pain Relevance 0.88
The postmitotic expression of Runx1 in neurons of the LPBS is consistent with postmitotic expression of this gene in motor and sensory neurons of the central nervous system (CNS) and peripheral nervous system (PNS), respectively.
Gene_expression (expression) of Runx1 in central nervous system associated with peripheral nervous system and central nervous system
13) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.44
Taken together, these data show that Runx1 is expressed from E12.5 to adulthood in a group of cells that comprise a population of postmitotic neurons within the dorsolateral rostral hindbrain.


Gene_expression (expressed) of Runx1 in neurons
14) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.07
Moreover, alterations in Runx1-expression in DRG cause perturbations in the outgrowth and axonal targeting of nociceptors, as well as in the response to thermal, neuropathic and inflammatory, but not mechanical, pain [8]–[12].
Gene_expression (expression) of Runx1 in nociceptors associated with pain, inflammation, nociceptor and neuropathic pain
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.50 Pain Relevance 0.80
However, we cannot exclude the possibility that the expression of Runx1 may end shortly before the last time point tested here, due to the ß-gal protein possibly having a longer half-life than that of Runx1.
Gene_expression (expression) of Runx1
16) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.40
Runx1 is expressed in postmitotic neurons of the LPBS from approximately E12.5 and its expression continues at least into young adulthood.
Gene_expression (expressed) of Runx1 in neurons
17) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.31
In the cervical spinal cord, Runx1 is expressed in restricted subpopulations of motor neurons, where it is important for the consolidation of motor neuron developmental programs, including the persistent suppression of interneuron-specific genes [13].
Gene_expression (expressed) of Runx1 in interneuron associated with interneuron and spinal cord
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.28
The expression of Runx1 within the neurons of the LPBS will undoubtedly provide both a useful marker and a genetic tool for future investigations into the development and precise functional role of this nucleus.


Gene_expression (expression) of Runx1 in nucleus
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.39 Pain Relevance 0.54
The aim of this study was to precisely characterize the expression of Runx1 in the developing and postnatal mouse brainstem.


Gene_expression (expression) of Runx1 in brainstem associated with medulla
20) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox