INT133212

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 11.16
Pain Relevance 11.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
nociceptor 8
neuronal 2
sensory neurons 1
neurons 1
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 472 99.98 Very High Very High Very High
trigeminal ganglion 678 99.90 Very High Very High Very High
nav1.8 17 99.74 Very High Very High Very High
Neuropeptide 50 99.68 Very High Very High Very High
Spinal cord 72 99.32 Very High Very High Very High
calcitonin gene related peptide 99 98.52 Very High Very High Very High
Neuropathic pain 180 98.36 Very High Very High Very High
mu opioid receptor 36 93.20 High High
opioid receptor 10 93.16 High High
substance P 27 92.96 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 939 99.90 Very High Very High Very High
Targeted Disruption 544 99.84 Very High Very High Very High
Neurodegenerative Disease 45 99.16 Very High Very High Very High
Neuropathic Pain 204 98.36 Very High Very High Very High
Nociception 78 98.16 Very High Very High Very High
Megacolon 36 98.00 Very High Very High Very High
Repression 78 96.36 Very High Very High Very High
Osteoporosis 3 92.84 High High
Nervous System Injury 24 92.68 High High
Pain 72 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Runx1a is therefore commonly viewed as a functional inhibitor of the Runx1 long isoform (Runx1b).
Negative_regulation (inhibitor) of Runx1b
1) Confidence 0.58 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.25 Pain Relevance 0.23
Since our findings in the in vitro experiments indicate that Runx1a has effects of its own, postnatal activation of Runx1a may not act as just a functional inhibitor of Runx1 long isoform activity.
Negative_regulation (inhibitor) of Runx1
2) Confidence 0.58 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.84 Pain Relevance 0.62
Runx1a is therefore commonly viewed as a functional inhibitor of the Runx1 long isoform (Runx1b).
Negative_regulation (inhibitor) of Runx1
3) Confidence 0.58 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.20 Pain Relevance 0.23
Given the ability of Runx1 to repress TrkB [23], it is very likely that the failure to discriminate TrkA+ and TrkB+ neural identities in the Brn3a-/- TG is due to the loss of Runx1 function, and that Runx1 performs an analogous function in nociceptor precursors to that of Runx3 in the TrkC lineage.
Negative_regulation (loss) of Runx1 in nociceptor associated with nociceptor and trigeminal ganglion
4) Confidence 0.55 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.74 Pain Relevance 0.47
Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain.
Negative_regulation (lacking) of Runx1 associated with neuropathic pain
5) Confidence 0.43 Published 2006 Journal Neuron Section Abstract Doc Link 16446141 Disease Relevance 0.48 Pain Relevance 0.68
Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain.
Negative_regulation (lacking) of Runx1 associated with neuropathic pain
6) Confidence 0.43 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853355 Disease Relevance 0.34 Pain Relevance 0.39
The remaining nociceptors switch off Runx1, most of which retain TrkA, although a subset of them expresses Ret [14].
Negative_regulation (switch) of Runx1 in nociceptors associated with nociceptor
7) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.97 Pain Relevance 1.37
To do this, we employed a genetic strategy that prevented Runx1 downregulation in most nociceptors.
Negative_regulation (downregulation) of Runx1 in nociceptors associated with nociceptor
8) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.76 Pain Relevance 1.06
The expression of Runx1 was restricted to post-mitotic neurons, and disruption of Runx1 resulted in massive neuronal apoptosis [22].
Negative_regulation (disruption) of Runx1 in neuronal associated with neurodegenerative disease
9) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.78 Pain Relevance 0.14
Microarray studies have shown decreased levels of Runx1 and Runx3 transcripts in the sensory neurons of Brn-3a-knokout mice [40,41].
Negative_regulation (decreased) of Runx1 in sensory neurons
10) Confidence 0.43 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.59 Pain Relevance 0.17
The size of the litters was reduced in DOX-activated Sox10-rtTA/TRE-Runx1a animals.
Negative_regulation (reduced) of Runx1a
11) Confidence 0.42 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.36 Pain Relevance 0.11
The reduction of neuronal differentiation could therefore be explained as a consequence of Runx1a-mediated functional inhibition of Runx1 activity.
Negative_regulation (inhibition) of Runx1 in neuronal
12) Confidence 0.42 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.15 Pain Relevance 0
Other neurological phenotypes of Runx1/Runx3 knockout mice
Negative_regulation (phenotypes) of Runx1 associated with targeted disruption
13) Confidence 0.42 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.66 Pain Relevance 0.11
In Brn3a knockout TG the Runx factors are markedly downregulated, leading to a failure to repress TrkB expression in TrkA- and TrkC-expressing neurons.
Negative_regulation (downregulated) of Runx in neurons associated with targeted disruption and trigeminal ganglion
14) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.21
These results are consistent with the hypothesis that much of the Brn3a-/- nociceptor phenotype is mediated by the loss of Runx1.
Negative_regulation (loss) of Runx1 in nociceptor associated with nociceptor
15) Confidence 0.41 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.51 Pain Relevance 0.76
Brn3a is required for the expression of a battery of Runx1-dependent nociceptor markers
Negative_regulation (battery) of Runx1-dependent in nociceptor associated with nociceptor
16) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.47 Pain Relevance 0.94
These results are also consistent with changes mediated by the loss of Runx1 in Brn3a knockouts.
Negative_regulation (loss) of Runx1
17) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.71 Pain Relevance 0.50
The emphasis of recent work on Runx1 has been on its role in late nociceptor development, and the effect of the loss of Runx1 on the initial discrimination of TrkA/TrkB-expressing precursors has not been reported.
Negative_regulation (loss) of Runx1 in nociceptor associated with nociceptor
18) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.15 Pain Relevance 0.29
The role of Runx1 in determining the final nociceptor gene expression profile is complex, in that the loss of Runx1 favors neuropeptide expression, and CGRP is repressed by ectopic expression of Runx1 [23], yet some functional genes associated with the peptidergic phenotype, such as Trpm8 and TrpA1, are Runx1-dependent [3].
Negative_regulation (loss) of Runx1 in nociceptor associated with calcitonin gene related peptide, nociceptor and neuropeptide
19) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.26 Pain Relevance 0.97
Thus, the timing of the onset of Runx1 expression and of TrkA/B discrimination, as well as the loss of Runx1 and TrkA/B discrimination in Brn3a knockouts, are consistent with a role for Runx1 in the repression of TrkB in TrkA/B precursors.
Negative_regulation (loss) of Runx1 associated with repression
20) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.49 Pain Relevance 0.17

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