INT133214

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 10.26
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDX1) generation of precursor metabolites and energy (PDX1) nucleus (PDX1)
cytoplasm (PDX1)
Anatomy Link Frequency
lungs 2
epithelial cells 1
PDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1045 100.00 Very High Very High Very High
rheumatoid arthritis 14 98.96 Very High Very High Very High
cytokine 15 96.40 Very High Very High Very High
palliative 96 94.32 High High
Inflammation 77 93.44 High High
spinal inflammation 4 46.00 Quite Low
corticosteroid 28 22.00 Low Low
alcohol 1 8.40 Low Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Idiopathic Pulmonary Fibrosis 840 100.00 Very High Very High Very High
Pulmonary Fibrosis 242 100.00 Very High Very High Very High
Cancer 37 100.00 Very High Very High Very High
Emphysema 29 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Rare Diseases 3 100.00 Very High Very High Very High
Rheumatoid Arthritis 17 98.96 Very High Very High Very High
Pulmonary Disease 94 98.84 Very High Very High Very High
Cicatrix 9 97.36 Very High Very High Very High
Fibrosis 112 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Medical therapy is ineffective in the treatment of IPF.
Regulation (ineffective) of IPF associated with fibrosis
1) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2330030 Disease Relevance 1.54 Pain Relevance 0.38
IPF is a rare disease which affects approximately 5 million persons worldwide.
Regulation (affects) of IPF associated with rare diseases and fibrosis
2) Confidence 0.34 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2330030 Disease Relevance 1.07 Pain Relevance 0.26
Their generalisability to practices that chose not to participate in the GSF programme cannot be assumed.
Regulation (participate) of GSF
3) Confidence 0.21 Published 2009 Journal Quality & Safety in Health Care Section Body Doc Link PMC2685539 Disease Relevance 0 Pain Relevance 0.28
To describe the general practices that participated in the GSF programme in 2003–5 and the changes in process and perception of quality that occurred in the year following entry into the programme, and to identify factors associated with the extent of change.


Regulation (participated) of GSF
4) Confidence 0.21 Published 2009 Journal Quality & Safety in Health Care Section Abstract Doc Link PMC2685539 Disease Relevance 0 Pain Relevance 0.32
The composite physiologic index (CPI) was derived to capture the effect of emphysema on IPF.
Regulation (effect) of IPF associated with fibrosis and emphysema
5) Confidence 0.21 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 2.54 Pain Relevance 0.57
In this sense, it is remarkable that we have been unable to clearly define the early changes in IPF/UIP.
Neg (unable) Regulation (changes) of IPF associated with fibrosis and idiopathic pulmonary fibrosis
6) Confidence 0.10 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 2.00 Pain Relevance 0.44
The comparison with COPD (Stage IV, n = 4), indicated that these alterations were specific for IPF i.e. no evidence for changes in these spots could be seen in the COPD lungs.
Neg (no) Regulation (specific) of IPF in lungs associated with fibrosis and pulmonary disease
7) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.92 Pain Relevance 0.29
Interestingly, osteopontin was colocalized with MMP-7 in alveolar epithelial cells of IPF lungs, and application of the weakest link models to microarray data suggested that the genes of both interacted to affect the IPF phenotype.
Regulation (affect) of IPF in epithelial cells associated with fibrosis
8) Confidence 0.03 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.53 Pain Relevance 0.20
It is unknown whether the expression of these receptors is changed in IPF; CD44 is expressed on lung fibroblasts and epithelial cells [43], is induced in radiation- and bleomycin-induced pulmonary fibrosis [44] and in acute alveolar fibrosis [45], and is critical for resolution of noninfectious lung inflammation [46].
Spec (whether) Regulation (changed) of IPF in lung associated with fibrosis, inflammation, pneumonia and pulmonary fibrosis
9) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.67 Pain Relevance 0.31
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
Regulation (affecting) of tumour necrosis factor promoter associated with necrosis, cancer and rheumatoid arthritis
10) Confidence 0.02 Published 2006 Journal Immunobiology Section Title Doc Link 16446172 Disease Relevance 0.98 Pain Relevance 0.30

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