INT133215

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.59
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
mesencephalon 1
ventral 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 11 99.50 Very High Very High Very High
midbrain 53 99.36 Very High Very High Very High
Dopamine 142 99.22 Very High Very High Very High
Ventral tegmentum 15 92.88 High High
Eae 8 54.76 Quite High
Substantia nigra 11 51.92 Quite High
Inflammation 48 50.00 Quite Low
Enkephalin 3 25.00 Low Low
cINOD 28 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 151 99.34 Very High Very High Very High
Hypertrophy 3 81.36 Quite High
Targeted Disruption 9 80.96 Quite High
Disease 128 80.64 Quite High
Toxicity 23 75.00 Quite High
Brain Tumor 1 74.20 Quite High
Cancer 9 69.56 Quite High
Aging 33 52.76 Quite High
INFLAMMATION 59 50.00 Quite Low
Apoptosis 13 24.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of the lesion and treatments were studied on striatal dopamine (DA) concentrations, dopamine and monoamine vesicular transporters (DAT and VMAT2), and preproenkephalin (PPE) mRNA levels.
Transcription (levels) of DAT associated with dopamine and monoamine
1) Confidence 0.67 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16446547 Disease Relevance 0.22 Pain Relevance 0.28
In contrast, DAT gene transcripts are not detected in the mouse ventral mesencephalon until DA axons reach the target at about E15, suggesting that during ontogeny, DA synthesis, and high-affinity uptake develop asynchronously and in a non-correlated fashion [27].
Neg (not) Transcription (detected) of DAT in mesencephalon associated with dopamine
2) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.37 Pain Relevance 0.41
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
Transcription (levels) of DAT associated with parkinson's disease
3) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.69 Pain Relevance 0.16
In addition, a comparative analysis of DAT and VMAT2 mRNA expressions in the ventral midbrain of rats revealed no differences between both mRNA expression patterns, with the highest levels in the SNrm, followed by the SNcv, and the lowest ones in VTA (Gonzalez-Hernandez et al., 2004).
Transcription (expressions) of DAT in ventral associated with ventral tegmentum and midbrain
4) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.31 Pain Relevance 0.10

General Comments

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