INT133234

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.22
Pain Relevance 4.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) response to stress (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
spinal 4
hypothalamus 2
striatum 2
forebrain 2
nucleus 2
Homer1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 5 99.84 Very High Very High Very High
spinal dorsal horn 17 99.68 Very High Very High Very High
amygdala 132 99.44 Very High Very High Very High
Sciatic nerve 4 99.40 Very High Very High Very High
dorsal root ganglion 21 99.38 Very High Very High Very High
projection neuron 12 98.82 Very High Very High Very High
Pain 2 98.70 Very High Very High Very High
Thermal hyperalgesia 6 98.60 Very High Very High Very High
Neuropathic pain 8 98.48 Very High Very High Very High
Nucleus accumbens 76 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 56 100.00 Very High Very High Very High
Nervous System Injury 5 99.84 Very High Very High Very High
Ganglion Cysts 23 99.38 Very High Very High Very High
Hyperalgesia 6 98.60 Very High Very High Very High
Neuropathic Pain 8 98.48 Very High Very High Very High
Injury 9 97.00 Very High Very High Very High
Hyperphagia 4 82.64 Quite High
Attention Deficit Hyperactivity Disorder 8 73.52 Quite High
Anxiety Disorder 8 66.72 Quite High
Stress 12 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data also imply that the early and transient up-regulation of Homer1a gene expression may be an important contributor to the eventual development of neuropathic pain.
Positive_regulation (regulation) of Gene_expression (expression) of Homer1a associated with neuropathic pain
1) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16448751 Disease Relevance 0.34 Pain Relevance 0.53
Loose ligation of the sciatic nerve in rats elicits transient up-regulation of Homer1a gene expression in the spinal dorsal horn.
Positive_regulation (regulation) of Gene_expression (expression) of Homer1a in spinal associated with pain, spinal dorsal horn and sciatic nerve
2) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16448751 Disease Relevance 0.29 Pain Relevance 0.55
These data also suggest that the transient and rapid increase in Homer1a expression may play an important role in the thermal hyperalgesia elicited by neural injury.
Positive_regulation (increase) of Gene_expression (expression) of Homer1a in neural associated with thermal hyperalgesia and injury
3) Confidence 0.69 Published 2009 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 19201745 Disease Relevance 1.05 Pain Relevance 0.79
These data show that CCD induces a transient and rapid increase in Homer1a expression in the spinal dorsal horn.
Positive_regulation (increase) of Gene_expression (expression) of Homer1a in spinal associated with dorsal root ganglion and spinal dorsal horn
4) Confidence 0.69 Published 2009 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 19201745 Disease Relevance 0.90 Pain Relevance 0.82
A product of an immediate early gene (IEG), the synaptic scaffolding protein Homer1a, has received increasing attention because it appears to play a critical role in synaptic plasticity.
Positive_regulation (immediate) of Gene_expression (product) of Homer1a
5) Confidence 0.43 Published 2009 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 19201745 Disease Relevance 0.70 Pain Relevance 0.60
Significant increases in homer1a expression were observed in striatal regions including the nucleus accumbens core and shell and the ventral and medial regions of the striatum.
Positive_regulation (increases) of Gene_expression (expression) of homer1a in striatum associated with nucleus accumbens
6) Confidence 0.24 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.35 Pain Relevance 0.20
An increase in homer1a expression was also found in limbic regions including the dorsal hippocampus and the basolateral amygdala, but not in the central nucleus of the amygdala.
Positive_regulation (increase) of Gene_expression (expression) of homer1a in nucleus associated with hippocampus and amygdala
7) Confidence 0.24 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.20 Pain Relevance 0.21
When rats are allowed to eat beyond satiety in the presence of a discrete cue that had been previously paired with food delivery when hungry, lateral hypothalamus projection neurons in the basolateral amygdala and prefrontal cortex exhibit increased homer1a and arc expression [58].
Positive_regulation (increased) of Gene_expression (expression) of homer1a in hypothalamus associated with aids-related complex, projection neuron and amygdala
8) Confidence 0.24 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.39 Pain Relevance 0.39
Ensure cues elicited homer1a expression in a variety of forebrain regions (Figure 3).
Positive_regulation (elicited) of Gene_expression (expression) of homer1a in forebrain
9) Confidence 0.16 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.12
Thus, synapsin-1 labeling distinctly revealed large clusters present at extrasynaptic sites, whereas co-transfection of EGFP-Homer1c and mCherry-gephyrin indicated that ┬ôsynaptic┬ö ?
Positive_regulation (transfection) of Gene_expression (co-transfection) of EGFP-Homer1c
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.23

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