INT133240

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.57
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) response to stress (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
CCD 1
dorsal horn 1
Homer1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 7 99.72 Very High Very High Very High
Dorsal horn 3 99.20 Very High Very High Very High
spinal dorsal horn 11 98.92 Very High Very High Very High
Neuropathic pain 4 97.40 Very High Very High Very High
Sciatic nerve 4 96.84 Very High Very High Very High
Eae 18 96.00 Very High Very High Very High
Hippocampus 42 92.60 High High
nMDA receptor 3 88.32 High High
Peripheral nerve injury 3 85.12 High High
antagonist 5 78.64 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 14 99.92 Very High Very High Very High
Ganglion Cysts 7 99.72 Very High Very High Very High
Neuropathic Pain 4 97.40 Very High Very High Very High
Injury 8 96.00 Very High Very High Very High
Nervous System Injury 3 85.12 High High
Hyperalgesia 2 76.24 Quite High
Cognitive Disorder 12 25.00 Low Low
Stress 7 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of Homer1a mRNA in the ipsilateral dorsal horn of CCD rats were markedly increased at 4 hr, remained elevated at 8 hr, and then returned to baseline values by 24 hr after CCD treatment.
Transcription (levels) of Homer1a in CCD associated with dorsal root ganglion and dorsal horn
1) Confidence 0.71 Published 2009 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 19201745 Disease Relevance 0.95 Pain Relevance 0.77
Significant increases in Homer1a mRNA levels in the ipsilateral dorsal horn were detected at 4h post-ligation, and these levels remained elevated at 8h before returning to baseline values by 24h after the ligation.
Transcription (levels) of Homer1a in dorsal horn associated with dorsal horn
2) Confidence 0.53 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16448751 Disease Relevance 0.23 Pain Relevance 0.43
In contrast, the levels of Homer1b/c mRNA did not change at any of these selected post-ligation times.
Transcription (levels) of Homer1
3) Confidence 0.52 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16448751 Disease Relevance 0.29 Pain Relevance 0.48
This motivational state was associated with increased transcription of the activity-regulated genes homer1a, arc, zif268, ngfi-b and c-fos in corticolimbic, thalamic and hypothalamic areas and of proenkephalin within striatal regions.
Transcription (transcription) of homer1a associated with aids-related complex
4) Confidence 0.19 Published 2007 Journal BMC Biol Section Abstract Doc Link PMC1868707 Disease Relevance 0.10 Pain Relevance 0.06
Thirty minutes following spatial training, there was a significant increase in the hippocampal transcript levels of Homer1a (2.6 fold), c-fos (1.8 fold), and zif268 (3.8 fold) relative to swim-control rats (Figure 6).


Transcription (transcript) of Homer1a
5) Confidence 0.07 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2911393 Disease Relevance 0 Pain Relevance 0.16

General Comments

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