INT133255

Context Info Confidence 0.41 First Reported 2005 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 8 Total Number 9 Disease Relevance 8.52 Pain Relevance 1.30

cytoskeletal protein binding (Anxa2) extracellular region (Anxa2) proteinaceous extracellular matrix (Anxa2) plasma membrane (Anxa2) protein complex (Anxa2) cytoplasm (Anxa2)

Anatomy Link Frequency monocyte 1 cortex 1 microglia 1 Anxa2 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 38 99.64 Inflammatory response 20 97.52 Chronic pancreatitis 4 93.92 Inflammatory stimuli 2 87.24 Inflammation 32 84.64 cytokine 11 81.64 Pyramidal cell 2 79.32 Spinal cord 24 78.40 palliative 1 51.84 Pain 3 27.44

Disease Link Frequency Relevance Heat Sprains And Strains 4 99.82 Fracture Healing 36 99.68 Fibrosis 4 99.08 Adenocarcinoma 16 98.86 Stomach Cancer 1 98.36 Infection 67 97.96 INFLAMMATION 53 97.52 Pancreatic Cancer 12 97.52 Cancer 70 97.32 Solid Tumor 4 94.28

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The up-regulated candidate genes ANXA2 and S100A8 encode two Ca2+-modulated proteins expressed in microglia and are implicated in the intracellular and extracellular regulation of inflammatory responses [92,93].

Gene_expression (expressed) of ANXA2 in microglia associated with inflammatory response

1) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.23 Pain Relevance 0.42

In the present study defense signaling comprises the only up-regulated GO categories in the SALS motor cortex, and is represented by numerous candidate genes, whose differential expression likely promotes (FCGBP, YWHAH, ANXA2, S100A8, EDN1, CEBPD) or suppresses (EGR1, metallothioneins) inflammatory responses, respectively.

Gene_expression (expression) of ANXA2 in cortex associated with inflammatory response

2) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.41 Pain Relevance 0.23

TNC expression was detected with increased frequency in the progression from PanIN-1 lesions to PDAC, and a parallel switch from cytoplasmic to cell surface expression of annexin II was observed.

Gene_expression (expression) of annexin II associated with adenocarcinoma

3) Confidence 0.05 Published 2006 Journal J. Pathol. Section Abstract Doc Link 16450333 Disease Relevance 1.02 Pain Relevance 0.09

Tenascin C and annexin II expression in the process of pancreatic carcinogenesis.

Gene_expression (expression) of annexin II

4) Confidence 0.05 Published 2006 Journal J. Pathol. Section Title Doc Link 16450333 Disease Relevance 0.65 Pain Relevance 0.05

The mRNA and protein levels of TNC and of annexin II were analysed in pancreatic tissues by DNA array, quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) and immunohistochemistry.

Spec (analysed) Gene_expression (levels) of annexin II

5) Confidence 0.05 Published 2006 Journal J. Pathol. Section Abstract Doc Link 16450333 Disease Relevance 0.59 Pain Relevance 0

In conclusion, the expression of TNC and cell surface annexin II increases in the progression from low-grade PanIN lesions to pancreatic cancer.

Gene_expression (expression) of annexin II associated with pancreatic cancer

6) Confidence 0.04 Published 2006 Journal J. Pathol. Section Abstract Doc Link 16450333 Disease Relevance 0.93 Pain Relevance 0.09

WNT1-induced secreted protein 1 (WISP1), a WNT target gene, is also expressed during fracture healing, and overexpression of this gene increases proliferation but decreases the differentiation in a chondrocytic cell line [21].

Gene_expression (expressed) of protein 1 associated with fracture healing

7) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.47 Pain Relevance 0

A comparative study using Plasmodium berghei ANKA infected C57BL/6 and BALB/c mice indicated th at both strains of mice expressed CXCL10 (interferon-induced protein 10, IP-10) and CCL2 (monocyte chemotactic protein-1, MCP-1) chemokine genes as early as 24 hours post-infection [12].

Gene_expression (expressed) of protein-1 in monocyte associated with chemokine, sprains and strains and infection

8) Confidence 0.01 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.23 Pain Relevance 0.36

Our previous studies demonstrated that CIAPIN1 confers multidrug resistance in gastric cancer cells possibly by upregulating multidrug resistance gene-1 and multidrug-related protein-1 expression (16).

Gene_expression (expression) of protein-1 associated with stomach cancer

9) Confidence 0.01 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.98 Pain Relevance 0.05

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