INT133262

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.03
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Csad) cellular_component (Csad)
Csad (Mus musculus)
Pain Link Frequency Relevance Heat
depression 14 100.00 Very High Very High Very High
Morphine 88 99.98 Very High Very High Very High
primary somatosensory cortex 56 99.78 Very High Very High Very High
Migraine 14 99.36 Very High Very High Very High
headache 2 93.96 High High
Anterior cingulate cortex 67 93.84 High High
Endep 2 85.56 High High
narcan 6 79.76 Quite High
agonist 6 76.64 Quite High
antagonist 6 75.68 Quite High
Disease Link Frequency Relevance Heat
Depression 14 100.00 Very High Very High Very High
Headache 10 99.36 Very High Very High Very High
Targeted Disruption 95 98.60 Very High Very High Very High
Migraine With Aura 6 97.36 Very High Very High Very High
Nociception 30 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
INTERPRETATION: Tonabersat showed a preventive effect on attacks of migraine aura but no efficacy on non-aura attacks, in keeping with its known inhibitory effect on CSD.
Negative_regulation (effect) of CSD
1) Confidence 0.50 Published 2009 Journal Lancet Neurol Section Body Doc Link 19570717 Disease Relevance 0 Pain Relevance 0
Longer treatment durations produced stronger CSD suppression.
Negative_regulation (suppression) of CSD
2) Confidence 0.37 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16450381 Disease Relevance 0.15 Pain Relevance 0
We hypothesized that migraine prophylactic agents suppress CSD as a common mechanism of action.
Negative_regulation (suppress) of CSD associated with depression and migraine
3) Confidence 0.37 Published 2006 Journal Ann. Neurol. Section Abstract Doc Link 16450381 Disease Relevance 0.81 Pain Relevance 0.67
Tonabersat inhibits CSD, and we therefore investigated whether tonabersat has a preventive effect in migraine with aura.
Negative_regulation (inhibits) of CSD associated with depression and migraine
4) Confidence 0.37 Published 2009 Journal Lancet Neurol Section Abstract Doc Link 19570717 Disease Relevance 0.57 Pain Relevance 0.42
In the S1, morphine decreased the CSD profile evoked by electrical stimulation to 61.5 ± 9.9% of the control amplitude in WT mice (n = 8) and 29.7 ± 6.7% of the control amplitude in KO mice (n = 6).
Negative_regulation (decreased) of CSD associated with targeted disruption, primary somatosensory cortex and morphine
5) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.51 Pain Relevance 1.43

General Comments

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