INT133269

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 9.77
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDX1) generation of precursor metabolites and energy (PDX1) nucleus (PDX1)
cytoplasm (PDX1)
Anatomy Link Frequency
lung 3
epithelial cell 2
fibroblasts 1
stage 3 1
PDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 777 100.00 Very High Very High Very High
Inflammation 147 100.00 Very High Very High Very High
chemokine 8 92.16 High High
palliative 3 91.76 High High
cva 2 78.72 Quite High
cytokine 12 28.64 Quite Low
metalloproteinase 27 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
corticosteroid 19 5.00 Very Low Very Low Very Low
positron emission tomography 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Idiopathic Pulmonary Fibrosis 550 100.00 Very High Very High Very High
Pulmonary Fibrosis 235 100.00 Very High Very High Very High
INFLAMMATION 153 100.00 Very High Very High Very High
Pulmonary Disease 28 100.00 Very High Very High Very High
Necrosis 15 99.76 Very High Very High Very High
Apoptosis 65 99.50 Very High Very High Very High
Death 32 98.52 Very High Very High Very High
Dyspnea 16 98.20 Very High Very High Very High
Fibrosis 171 93.36 High High
Lung Injury 14 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pdx1, Cdx1, and FoxA3 expression was induced in “stage 3,” when cell clusters were allowed to adhere to pre-coated wells at a density of 40–80 NSs/cm2 and cultured in low-glucose medium with 2 ?
Positive_regulation (induced) of Pdx1 in stage 3
1) Confidence 0.54 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 1.00 Pain Relevance 0
Two general practices that had adopted the GSF were recruited in each of four geographical areas, and each matched as closely as possible with a non-GSF practice.
Positive_regulation (adopted) of GSF
2) Confidence 0.43 Published 2005 Journal Palliat Med Section Abstract Doc Link 16450879 Disease Relevance 0 Pain Relevance 0.23
The diagnosis, in the setting of known IPF, requires all of the following: a) acute worsening of dyspnea within the last month; b) deterioration from baseline of either vital capacity or gas exchange (usually documented by a wide A-a gradient); c) new radiographic infiltrates; and d) the absence of alternative causes for clinical deterioration [28].
Positive_regulation (requires) of IPF associated with fibrosis and dyspnea
3) Confidence 0.38 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.75 Pain Relevance 0.65
cell precursors here, at 21 days of coculture, when c-kit and PDX-1 transcription factors are upregulated in a pancreatic neogenesis model.
Positive_regulation (upregulated) of PDX-1
4) Confidence 0.38 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Likewise, an increase in PDX-1 and c-kit mRNA also was observed.
Positive_regulation (increase) of PDX-1
5) Confidence 0.38 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
The ratio of FEV1/FVC remains normal (or increased) in IPF, consistent with restrictive physiology.
Positive_regulation (increased) of IPF associated with fibrosis
6) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.28 Pain Relevance 0.26
The remaining cells coexpress either insulin, or epithelial cell markers [5] or pancreatic and duodenal homeobox gene-1 (PDX-1), which regulates glucose-stimulated insulin gene expression [9].
Positive_regulation (glucose-stimulated) of PDX-1 in epithelial cell
7) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0.28 Pain Relevance 0
-cells, (Figure 4) declined progressively in the NPI cell monolayers cocultured with ESC, as compared to untreated NPI cell monolayers however, difference was statistically significant only for the 21 day-treated NPI (P < .050); (b) the percentage of NPI double positive for PDX-1/insulin, a mature  ?
Positive_regulation (percentage) of PDX-1
8) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
WB densitometric analysis has revealed an increase of phosphorylated PDX-1 in the treated (statistically significative at 21 days) as compared to the control monolayers.
Positive_regulation (increase) of PDX-1
9) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Interestingly, coculture of our cell monolayers with microencapsulated SC induced an increase in PDX-1+/insulin+ and c-kit+/insulin+ cell percentage, according to previous observations by the use of SCF [31] in either fetal human [17] or rat [28] islet experimental settings.
Positive_regulation (increase) of PDX-1
10) Confidence 0.24 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
A number of studies performed both in vitro and in vivo support the notion that epithelial programmed cell death and necrosis are highly increased in IPF lungs.
Positive_regulation (increased) of IPF in lungs associated with fibrosis, necrosis and apoptosis
11) Confidence 0.12 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 1.65 Pain Relevance 0.14
These results strongly suggest that the Fas signalling pathway is upregulated in lung epithelial cells during IPF.
Positive_regulation (upregulated) of IPF in lung associated with fibrosis
12) Confidence 0.12 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 1.40 Pain Relevance 0.22
Their concentration is elevated in certain inflammatory lung diseases, including IPF [12].
Positive_regulation (elevated) of IPF in lung associated with pulmonary disease and inflammation
13) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.60 Pain Relevance 0.10
Moreover, it was recently reported that the immunoreactivity for the Fas-associated death domain protein as well as for caspase-1 and caspase-3 were significantly increased in alveolar epithelial cells of IPF compared with controls [28].
Positive_regulation (increased) of IPF in epithelial cells associated with fibrosis and death
14) Confidence 0.08 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 1.46 Pain Relevance 0.26
Is CCL18, that stimulates lung fibroblasts to produce collagen, the key to a potential new treatment in IPF [29]?
Positive_regulation (treatment) of IPF in fibroblasts
15) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.34 Pain Relevance 0.05

General Comments

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