INT133283

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
CPA 2
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 95.12 Very High Very High Very High
adenocard 6 93.08 High High
GABAergic 4 91.24 High High
Dopamine 1 86.04 High High
Enkephalin 2 25.00 Low Low
Somatostatin 4 14.72 Low Low
imagery 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 39 89.40 High High
Neurodegenerative Disease 1 75.36 Quite High
Colon Cancer 1 69.84 Quite High
Apoptosis 6 55.84 Quite High
Adenoma 7 29.60 Quite Low
Cancer 22 11.84 Low Low
Acromegaly 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present work, by studying co-localization of c-Fos immunoreactivity and preproenkephalin and preprodynorphin transcripts, we show that co-administration of the A1 receptor agonist CPA and the A2A receptor agonist CGS 21680 increases the striatal expression of c-fos in GABAergic enkephalinergic but not in GABAergic dynorphinergic neurons.
Negative_regulation (studying) of Localization (co-localization) of c-Fos in CPA associated with gabaergic and agonist
1) Confidence 0.41 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16452987 Disease Relevance 0 Pain Relevance 0.46
The potential target genes of miR-145 encode oncogenic proteins, such as myc, kras, fos, yes, fli, cyclin D2, and MAPK transduction proteins [31]. miR-145 targets the insulin receptor substrate-1 (IRS-1) and miR-151-3p targets the insulin receptor substrate-4 (IRS-4), which regulated cell communication, receptor and membrane activities.
Negative_regulation (yes) of Localization (kras) of fos
2) Confidence 0.08 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.29 Pain Relevance 0

General Comments

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