INT13329

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
NFKBIL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Analgesic 1 99.68 Very High Very High Very High
Kappa opioid receptor 2 96.20 Very High Very High Very High
opiate 1 83.16 Quite High
Nucleus accumbens 3 78.72 Quite High
Thalamus 2 76.80 Quite High
Central grey 1 74.20 Quite High
amygdala 1 62.20 Quite High
withdrawal 16 50.00 Quite Low
parabrachial 1 44.20 Quite Low
Disease Link Frequency Relevance Heat
Persistent Vegetative State 42 50.00 Quite Low
Injury 6 28.76 Quite Low
Death 16 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Neurologic Manifestations 6 5.00 Very Low Very Low Very Low
Brain Injury 4 5.00 Very Low Very Low Very Low
Coma 2 5.00 Very Low Very Low Very Low
Brain Death 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Unconsciousness 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuroanatomical localization of kappa 1 and kappa 2 opioid receptors in rat and guinea pig brain.
Localization (localization) of kappa 1 in brain associated with analgesic and opioid receptor
1) Confidence 0.69 Published 1991 Journal Brain Res. Section Title Doc Link 1666016 Disease Relevance 0 Pain Relevance 0.43
Society may not impose objective QoL assessments to facilitate removal of LST from individuals perceived as unworthy or useless without risking the welfare of entire populations of disabled or otherwise disenfranchized citizens.
Localization (removal) of LST
2) Confidence 0.62 Published 2004 Journal Crit Care Section Body Doc Link PMC420027 Disease Relevance 0 Pain Relevance 0
This conflict forces several issues: what level of evidence is required to justify removal of LST, which standard of surrogacy should be applied, and how ought QoL and the preservation of life be balanced?
Localization (removal) of LST
3) Confidence 0.62 Published 2004 Journal Crit Care Section Body Doc Link PMC420027 Disease Relevance 0 Pain Relevance 0
These findings fit in with our data on kappa-OR protein distribution.
Localization (distribution) of kappa-OR protein associated with opioid receptor
4) Confidence 0.42 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7478266 Disease Relevance 0 Pain Relevance 0.39

General Comments

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