INT133304

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
neuronal 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 2 91.00 High High
cytokine 23 79.76 Quite High
Neuropathic pain 1 75.00 Quite High
Arthritis 4 33.36 Quite Low
Central nervous system 1 30.32 Quite Low
Pain 2 25.00 Low Low
Inflammation 13 12.24 Low Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 89.08 High High
Neuropathic Pain 1 75.00 Quite High
Experimental Arthritis 4 33.36 Quite Low
Multiple Sclerosis 17 22.64 Low Low
INFLAMMATION 13 12.24 Low Low
Inflammatory Bowel Disease 7 7.60 Low Low
Autoimmune Disease 13 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 5 5.00 Very Low Very Low Very Low
Leukemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also sought to determine which neuronal phenotypes are affected and to examine the effect of aldose reductase inhibition on JNK and c-Jun phosphorylation.
Spec (examine) Regulation (effect) of Phosphorylation (phosphorylation) of c-Jun in neuronal
1) Confidence 0.33 Published 2006 Journal Diabetologia Section Abstract Doc Link 16456679 Disease Relevance 0.24 Pain Relevance 0.07
Thus, in our case statistically insignificant reduction of p-JNK concentration in cells could result in significant down-regulation of Jun phosphorylation.
Regulation (regulation) of Phosphorylation (phosphorylation) of Jun
2) Confidence 0.20 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.09

General Comments

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