INT133307

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.60
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44, SPP1) extracellular space (SPP1) extracellular region (SPP1)
plasma membrane (CD44) cytoplasm (SPP1)
Anatomy Link Frequency
extracellular matrix 2
osteoblasts 1
CD44 (Homo sapiens)
SPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 72 94.24 High High
cytokine 5 89.84 High High
Inflammation 3 72.08 Quite High
anesthesia 4 70.48 Quite High
metalloproteinase 60 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 9 99.00 Very High Very High Very High
Hypercalcemia 24 98.70 Very High Very High Very High
Pulmonary Fibrosis 65 94.24 High High
Cancer 130 91.36 High High
Increased Venous Pressure Under Development 1 87.32 High High
Fibrosis 9 77.52 Quite High
Metastasis 78 75.00 Quite High
Carcinoma 18 75.00 Quite High
Pneumonia 1 72.48 Quite High
Lung Cancer 9 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In general it has been proposed that osteopontin affects cells by binding to CD44 isoforms, certain integrins, and EGFR [41,42].
CD44 Binding (binding) of osteopontin
1) Confidence 0.26 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.62 Pain Relevance 0.28
OPN/CD44 interaction was shown to be required for cell migration and CD44 synthesis [6].
CD44 Binding (interaction) of OPN
2) Confidence 0.24 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
OPN/CD44 interaction was shown to be required for cell migration and CD44 synthesis [6].
CD44 Binding (interaction) of OPN
3) Confidence 0.24 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Based on this observation, we suggest that the failure of interaction of OPN with CD44 by anti-CD44 may reduce CD44 synthesis and surface expression.
CD44 Binding (interaction) of OPN
4) Confidence 0.21 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Based on this observation, we suggest that the failure of interaction of OPN with CD44 by anti-CD44 may reduce CD44 synthesis and surface expression.
CD44 Binding (interaction) of OPN
5) Confidence 0.18 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
We thus speculated that, mediating its affinity for CD44, osteopontin may serve to facilitate osteoclastic migration after their formation associated with ALPase-positive osteoblasts.
CD44 Binding (affinity) of osteopontin in osteoblasts associated with osteoporosis
6) Confidence 0.17 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.83 Pain Relevance 0.07
Thus, osteoclasts appear to either select an optimized function, namely secreting proteolytic enzymes from ruffled borders during bone resorption, or recognize the surrounding extracellular matrix by mediating osteopontin/CD44 interaction, and internalize the extracellular matrices.
CD44 Binding (interaction) of osteopontin in extracellular matrix associated with hypercalcemia
7) Confidence 0.12 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.57 Pain Relevance 0
Thus, osteoclasts appear to either select an optimized function, namely secreting proteolytic enzymes from ruffled borders during bone resorption, or recognize the surrounding extracellular matrix by mediating osteopontin/CD44 interaction, and internalize the extracellular matrices.
CD44 Binding (interaction) of osteopontin in extracellular matrix associated with hypercalcemia
8) Confidence 0.12 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.57 Pain Relevance 0

General Comments

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