INT133312

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 16.79
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
plasma 1
ECM 1
osteoclasts 1
heart 1
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 499 100.00 Very High Very High Very High
depression 35 97.64 Very High Very High Very High
rheumatoid arthritis 142 97.46 Very High Very High Very High
Multiple sclerosis 84 97.16 Very High Very High Very High
Osteoarthritis 17 96.64 Very High Very High Very High
cytokine 61 94.72 High High
Angina 8 94.08 High High
alcohol 58 91.32 High High
Inflammation 157 88.20 High High
Arthritis 20 81.44 Quite High
Disease Link Frequency Relevance Heat
Metastasis 228 99.76 Very High Very High Very High
Cancer 574 99.20 Very High Very High Very High
Prostate Cancer 440 99.20 Very High Very High Very High
Stomach Cancer 29 98.88 Very High Very High Very High
Death 6 98.68 Very High Very High Very High
Wound Healing 15 98.48 Very High Very High Very High
Apoptosis 71 97.92 Very High Very High Very High
Hypercalcemia 73 97.88 Very High Very High Very High
Depression 38 97.64 Very High Very High Very High
Rheumatoid Arthritis 142 97.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multivariate regression models adjusting for age, sex and variables with highly significant associations to MMP-9 in univariate analyses (p<0.001) were performed in addition. 3) Both the total risk load model and the regression models on single risk factors were performed with and without adjustment for CRP.
MMP-9 Binding (associations) of
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.45 Pain Relevance 0.04
We found a highly significant association between plasma MMP-9 levels and number of risk factors added (+5.7 ng/mL (95% CI 3.6;7.7) per additional risk factor. p<0.001).
MMP-9 Binding (association) of in plasma
2) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.07 Pain Relevance 0
The percentage of immunoreactive positive cells and intensity for MMP9, MMP2, type IV collagen in GC were assessed.
MMP9 Binding (intensity) of associated with stomach cancer
3) Confidence 0.34 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.34 Pain Relevance 0
MMP9 has been associated with angiogenesis, tumour progression and metastasis as mediated through degradation of the extracellular matrix (ECM) [41] and stimulation of hyperproliferation [42].
MMP9 Binding (associated) of in ECM associated with cancer and metastasis
4) Confidence 0.34 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.37 Pain Relevance 0.03
Adjusting for age and sex, level of MMP-9 was significantly associated to the single risk factors waist circumference, SBP, heart rate, low HDL, triglycerides and CRP apart from each of the four behavioral factors tested.
MMP-9 Binding (associated) of in heart associated with disorder of lipid metabolism
5) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0.40 Pain Relevance 0.15
Activated MMP1, MMP3, and latent forms of MMP2 and MMP9 bind to and are inhibited by TIMP1 and TIMP2.
MMP9 Binding (bind) of
6) Confidence 0.32 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.67 Pain Relevance 0.50
In the established experimental system, the neutralization of TIMP-2 with purified IgG interfered with TIMP-2 binding to the catalytic domain of MMP9.
MMP9 Binding (binding) of
7) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.62 Pain Relevance 0.29
Bearing in mind the significant difference in the pattern of erosivity between RA patients with and those without TIMP-2 specific autoantibodies, we decided to analyse whether these immunoglobulins supported MMP9 activity by neutralizing TIMP-2.
MMP9 Binding (activity) of associated with rheumatoid arthritis
8) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.49 Pain Relevance 0.33
Immunostaining analysis revealed that the interaction of hZip-1 with either CD44 or MMP-9 was negligible or not at all observed (data not shown).
MMP-9 Binding (interaction) of
9) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.21 Pain Relevance 0
Gelatin zymography exhibited gelatinolytic activity of both MMP-2 and MMP-9 in the conditioned media (Figure 1B).
MMP-9 Binding (activity) of
10) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.43 Pain Relevance 0.05
MMP-2 and MMP-9 are associated with metastasis of prostate cancer cells to bone [18].
MMP-9 Binding (associated) of associated with prostate cancer and metastasis
11) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.81 Pain Relevance 0.27
The effects of BPs on the surface interaction of MMP-9 and CD44
MMP-9 Binding (interaction) of
12) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.26 Pain Relevance 0.03
The effect of BPs on the surface interaction of CD44 and MMP-9 was analyzed by immunostaining analysis with respective antibodies in cells that were neither fixed with paraformaldehyde nor permeablized with Triton X-100 (Figure 5).
MMP-9 Binding (interaction) of
13) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.21 Pain Relevance 0
Disruption of CD44/MMP-9 cluster formation, by over expression of soluble or truncated cell surface CD44 reduces tumor invasiveness in vivo [19].
MMP-9 Binding (formation) of associated with cancer
14) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.96 Pain Relevance 0.31
We show here the inhibitory effect of bisphosphonates (e.g. alendronate and pamidronate) on MMP-9 activity, CD44 surface expression, cell surface CD44/MMP-9 interaction, and migration (Figs. 4 and 5); without increasing apoptosis of cells.
MMP-9 Binding (interaction) of associated with apoptosis
15) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.51 Pain Relevance 0.08
CD44/MMP-9 complex formation on the cell surface may represent a unique motility-enhancing signal in prostate cancer cells, thereby promoting their invasiveness.


MMP-9 Binding (formation) of associated with prostate cancer
16) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.14 Pain Relevance 0.15
These observations suggest that CD44/MMP-9 interaction on the cell surface has a role in tumor progression [19].
MMP-9 Binding (interaction) of associated with cancer
17) Confidence 0.27 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.68 Pain Relevance 0.04
Attenuation of Rho GTPase activation by BPs may have contributed to the down regulation of cell surface CD44/MMP-9 interaction, MMP-9 activation/secretion, and cell migration.
MMP-9 Binding (interaction) of
18) Confidence 0.27 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.16 Pain Relevance 0
Immunoelectron microscopy disclosed the presence of MMP-9 in the Golgi apparatus and in vesicular structures at the baso-lateral cytoplasmic region of the osteoclasts found in the stromal tissue.
MMP-9 Binding (presence) of in osteoclasts
19) Confidence 0.25 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.55 Pain Relevance 0.05
PC3 cells secrete active MMP-9 (Figures 1 and 4) although the interaction of both pro- and active MMP-9 was observed on the cell surface.
MMP-9 Binding (interaction) of
20) Confidence 0.23 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.11 Pain Relevance 0

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