INT133316

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.43
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSK) extracellular space (CTSK) lysosome (CTSK)
cytoplasm (CTSK)
Anatomy Link Frequency
osteoclasts 3
CTSK (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 6 89.48 High High
methotrexate 6 81.36 Quite High
rheumatoid arthritis 91 78.40 Quite High
metalloproteinase 4 64.56 Quite High
anesthesia 1 63.84 Quite High
Inflammation 17 50.56 Quite High
cytokine 8 36.16 Quite Low
Osteoarthritis 40 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 41 99.96 Very High Very High Very High
Osteoporosis 49 99.64 Very High Very High Very High
Postmenopausal Osteoporosis 23 96.88 Very High Very High Very High
Cancer 8 85.92 High High
Rheumatoid Arthritis 91 78.40 Quite High
Metastasis 9 75.00 Quite High
Carcinoma 2 75.00 Quite High
Disease 45 72.12 Quite High
Lung Cancer 1 57.24 Quite High
INFLAMMATION 19 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cathepsin K is essential for bone resorption, which depends on the production of cathepsin K by osteoclasts and its secretion into the extracellular department.
Localization (secretion) of cathepsin K in osteoclasts associated with hypercalcemia
1) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.57 Pain Relevance 0.18
In vivo the activation of cathepsin K occurs intracellularly, before secretion into the resorbing lacunae and the onset of bone resorption, whereby local factors may regulate the processing of procathepsin K to mature cathepsin K [23].
Localization (secretion) of cathepsin K associated with hypercalcemia
2) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.47 Pain Relevance 0.15
Cathepsin K, a protease secreted by osteoclasts, is another potential therapeutic target for the treatment of postmenopausal osteoporosis.
Localization (secreted) of Cathepsin K in osteoclasts associated with postmenopausal osteoporosis
3) Confidence 0.29 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.30 Pain Relevance 0
Determination of functional metalloprotease-13 and cathepsin K
Localization (metalloprotease-13) of cathepsin K
4) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0 Pain Relevance 0
We next examined the localization of cathepsin K and matrix metallo-proteinase-9 (MMP-9) in osteoclasts.
Spec (examined) Localization (localization) of cathepsin K in osteoclasts
5) Confidence 0.13 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.80 Pain Relevance 0.06
During osteoclastic bone resorption, cathepsin K and other proteases release peptide bound crosslinks, attached to fragments of C-terminal (CTX) or N-terminal (NTX) telopeptides [33,34].
Localization (release) of cathepsin K associated with hypercalcemia and osteoporosis
6) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.29 Pain Relevance 0.03

General Comments

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