INT133317

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44) plasma membrane (CD44)
Anatomy Link Frequency
extracellular matrix 2
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 34.48 Quite Low
Inflammation 125 5.00 Very Low Very Low Very Low
Nicotine 40 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
transdermal 8 5.00 Very Low Very Low Very Low
Angina 8 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 7 99.92 Very High Very High Very High
Nicotine Addiction 732 99.80 Very High Very High Very High
Hypercalcemia 1 98.90 Very High Very High Very High
Adhesions 372 97.68 Very High Very High Very High
Cancer 46 78.96 Quite High
Dermatological Disease 4 76.28 Quite High
Psoriasis 4 75.24 Quite High
Metastasis 19 75.00 Quite High
Carcinoma 14 75.00 Quite High
Osteoporosis 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, osteoclasts appear to either select an optimized function, namely secreting proteolytic enzymes from ruffled borders during bone resorption, or recognize the surrounding extracellular matrix by mediating osteopontin/CD44 interaction, and internalize the extracellular matrices.
Positive_regulation (mediating) of CD44 Binding (interaction) of in extracellular matrix associated with hypercalcemia
1) Confidence 0.55 Published 2006 Journal Microsc. Res. Tech. Section Abstract Doc Link 16456838 Disease Relevance 0.58 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (increase) of CD44 Binding (concentrations) of associated with nicotine addiction
2) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.40 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (causes) of CD44 Binding (concentrations) of associated with nicotine addiction
3) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.40 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (causes) of CD44 Binding (concentrations) of associated with nicotine addiction
4) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.40 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (increase) of CD44 Binding (concentrations) of associated with nicotine addiction
5) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.40 Pain Relevance 0
Enhanced binding of HA to pericellular hyaladherins and MPC receptors (for example, CD44) upregulated by PPS, however, could also be a consideration.
Positive_regulation (Enhanced) of CD44 Binding (binding) of
6) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.10 Pain Relevance 0

General Comments

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