INT133324

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
fibroblast 2
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.42 Very High Very High Very High
Cannabinoid receptor 1 99.26 Very High Very High Very High
Cannabinoid 8 96.94 Very High Very High Very High
Analgesic 1 72.32 Quite High
cannabis 1 67.16 Quite High
Disease Link Frequency Relevance Heat
Leukemia 1 96.72 Very High Very High Very High
Cancer 2 86.84 High High
Appetite Loss 1 73.76 Quite High
Vomiting 1 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike the known P-gp inhibitor, PSC833, short 1h exposure to three plant-derived cannabinoids, cannabinol (CBN), cannabidiol (CBD) and Delta(9)-tetrahydrocannabinol (THC) and the synthetic cannabinoid receptor agonist, WIN55, 212-2 (WIN) did not inhibit the efflux of the P-gp substrate Rhodamine 123 (Rh123) in either a drug-selected human T lymphoblastoid leukaemia cell line (CEM/VLB(100)) or in a mouse fibroblast MDR1 transfected cell line (77.1).
Negative_regulation (inhibit) of Localization (efflux) of P-gp in fibroblast associated with leukemia, cannabinoid receptor, cannabinoid and agonist
1) Confidence 0.12 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.41 Pain Relevance 0.44

General Comments

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