INT13333

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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.37
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
cerebellum 4
nucleus accumbens 2
cortex 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 360 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
dopamine receptor 41 99.98 Very High Very High Very High
Inflammation 29 99.36 Very High Very High Very High
Morphine 8 98.68 Very High Very High Very High
Nucleus accumbens 6 94.68 High High
mu opioid receptor 1 94.48 High High
antagonist 18 91.44 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 270 99.90 Very High Very High Very High
INFLAMMATION 29 99.36 Very High Very High Very High
Cognitive Disorder 36 94.52 High High
Hyperinsulinism 3 79.84 Quite High
Congenital Anomalies 6 65.24 Quite High
Nociception 13 62.16 Quite High
Opiate Addiction 1 58.24 Quite High
Cerebellar Diseases 9 56.88 Quite High
Pain 23 52.56 Quite High
Schizophrenia 3 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the relative inhibitory effect of the mu-opioid receptor agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO) on dopamine D1 receptor-stimulated cyclic AMP production was unchanged after exposure to morphine.
Regulation (effect) of Gene_expression (production) of dopamine D1 associated with dopamine, agonist, enkephalin, opioid receptor and morphine
1) Confidence 0.36 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1666051 Disease Relevance 0.06 Pain Relevance 1.15
RESULTS: Naltrexone treatment significantly decreased preprodynorphin expression in the nucleus accumbens, but neither naltrexone treatment nor ethanol consumption significantly affected dopamine D1 and D2 receptor mRNA expression.
Neg (neither) Regulation (affected) of Gene_expression (expression) of dopamine D1 in nucleus accumbens
2) Confidence 0.33 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 11505043 Disease Relevance 0 Pain Relevance 0
Our study showed that diabetes can regulate the expression of dopamine D1 receptor which may reduce the central cortical function.
Regulation (regulate) of Gene_expression (expression) of dopamine D1 receptor associated with dopamine and diabetes mellitus
3) Confidence 0.31 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.82 Pain Relevance 0.49
In agreeable with the total dopamine receptor change in the cerebellum dopamine D1 receptor expression was down regulated in the diabetic rats when compared to control.
Regulation (change) of Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with dopamine, diabetes mellitus and dopamine receptor
4) Confidence 0.31 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.78 Pain Relevance 0.57
In agreeable with the total dopamine receptor change in the cerebellum dopamine D1 receptor expression was down regulated in the diabetic rats when compared to control.
Regulation (regulated) of Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with dopamine, diabetes mellitus and dopamine receptor
5) Confidence 0.14 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.79 Pain Relevance 0.57
cortex, D1 receptor activation typically inhibits IRKC by direct effects of cAMP on IRK channels, but strong
Regulation (effects) of Gene_expression (activation) of D1 receptor in cortex
6) Confidence 0.10 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.18
In contrast, the expression of D1 receptor mRNA was modified in the opposite way by the reserpine/AMPT treatment.
Regulation (modified) of Gene_expression (expression) of D1 receptor mRNA
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.60
This experiment evaluated if the same inflammatory process as above could produce changes in the expression of dopamine D1 and D2 receptors' mRNA levels in the IC.
Regulation (changes) of Gene_expression (expression) of dopamine D1 associated with dopamine and inflammation
8) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2994804 Disease Relevance 0.92 Pain Relevance 0.73

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