INT13334

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 43
Total Number 45
Disease Relevance 7.73
Pain Relevance 24.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 6
striatum 3
cerebellum 3
cortex 3
caudate-putamen 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1525 100.00 Very High Very High Very High
dopamine receptor 233 100.00 Very High Very High Very High
agonist 199 100.00 Very High Very High Very High
Enkephalin 64 100.00 Very High Very High Very High
Neuropeptide 36 100.00 Very High Very High Very High
Dynorphin 21 100.00 Very High Very High Very High
substance P 20 100.00 Very High Very High Very High
Central nervous system 16 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
antagonist 123 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperinsulinism 6 99.90 Very High Very High Very High
Diabetes Mellitus 540 99.64 Very High Very High Very High
INFLAMMATION 84 99.06 Very High Very High Very High
Schizophrenia 33 98.88 Very High Very High Very High
Urological Neuroanatomy 15 96.00 Very High Very High Very High
Eating Disorder 4 94.56 High High
Cognitive Disorder 81 94.00 High High
Stress 61 93.76 High High
Alcohol Addiction 2 92.88 High High
Cerebellar Diseases 18 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the relative inhibitory effect of the mu-opioid receptor agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO) on dopamine D1 receptor-stimulated cyclic AMP production was unchanged after exposure to morphine.
Gene_expression (production) of dopamine D1 associated with dopamine, agonist, enkephalin, opioid receptor and morphine
1) Confidence 0.62 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1666051 Disease Relevance 0.06 Pain Relevance 1.14
Striatal neurons that express the D-1 DA receptor coexpress dynorphin and substance P, and CREB is known to couple D-1 DA receptor stimulation to preprodynorphin (ppD) gene expression.
Gene_expression (express) of D-1 DA receptor in neurons associated with dopamine, dynorphin and substance p
2) Confidence 0.60 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.08 Pain Relevance 0.77
However, in the caudate putamen, the mRNA levels, for dopamine D2 and adenosine 2A receptor, dynorphin, and substance P were lower during the day than during the night, whereas the expression of dopamine D1 receptor, enkephalin, and somatostatin was stable.
Gene_expression (expression) of dopamine D1 receptor in caudate putamen associated with adenocard, dopamine, dynorphin, somatostatin, enkephalin and substance p
3) Confidence 0.59 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15016424 Disease Relevance 0.33 Pain Relevance 0.75
The A2a receptor is mainly expressed by neurons projecting to the globus pallidus and expressing also the dopamine D2 receptor and enkephalin, but very sparsely by neurons projecting to the substantia nigra that express the dopamine D1 receptor and substance P.
Gene_expression (express) of dopamine D1 receptor in substantia nigra associated with dopamine, substantia nigra, enkephalin and substance p
4) Confidence 0.58 Published 1993 Journal J. Neurosci. Section Abstract Doc Link 7680065 Disease Relevance 0.07 Pain Relevance 0.64
SK&F 87516, a close analog of fenoldopam, is a partial agonist at dopamine-1 and alpha-2 receptors and produces stimulation of 5-hydroxytryptamine-2 receptors in the cardiovascular system of the rat.
Gene_expression (produces) of dopamine-1 in cardiovascular system associated with dopamine and agonist
5) Confidence 0.57 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1672375 Disease Relevance 0.14 Pain Relevance 0.30
[Participation of D1 dopamine and alpha2 adrenoreceptors in formation of the frequency spectrum of the cortical activity in rats].
Gene_expression ([Participation) of D1 dopamine associated with dopamine
6) Confidence 0.52 Published 2000 Journal Eksp Klin Farmakol Section Title Doc Link 10934587 Disease Relevance 0 Pain Relevance 0.52
Mismatches between dopamine innervation and dopamine D1 receptor (D1) distribution have previously been demonstrated in the intercalated cell masses of the rat amygdala.
Gene_expression (distribution) of dopamine D1 in amygdala associated with dopamine and amygdala
7) Confidence 0.52 Published 2006 Journal Neuroscience Section Abstract Doc Link 16820264 Disease Relevance 0 Pain Relevance 0.72
Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats.
Gene_expression (expression) of D-1 dopamine receptor in caudate-putamen associated with nucleus accumbens, dopamine receptor, neuropeptide, agonist and enkephalin
8) Confidence 0.47 Published 2005 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 1.02
Striatal neurons that express the D-1 DA receptor coexpress dynorphin and substance P, and CREB is known to couple D-1 DA receptor stimulation to preprodynorphin (ppD) gene expression.
Gene_expression (coexpress) of D-1 DA receptor in neurons associated with dopamine, dynorphin and substance p
9) Confidence 0.47 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.08 Pain Relevance 0.77
It is clear from these studies that different stages of the cocaine use cycle are characterized by distinct patterns of prodynorphin and dopamine D1 mRNA expression levels.
Gene_expression (expression) of dopamine D1 mRNA associated with dopamine and cocaine
10) Confidence 0.47 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10415667 Disease Relevance 0.14 Pain Relevance 1.32
We describe here the effect of free-choice ethanol consumption and naltrexone treatment on preproenkephalin, preprodynorphin, and dopamine D1 and D2 receptor mRNA expression in the central nervous system.
Gene_expression (expression) of dopamine D1 in central nervous system associated with dopamine and central nervous system
11) Confidence 0.41 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 11505043 Disease Relevance 0.09 Pain Relevance 0.27
RESULTS: Naltrexone treatment significantly decreased preprodynorphin expression in the nucleus accumbens, but neither naltrexone treatment nor ethanol consumption significantly affected dopamine D1 and D2 receptor mRNA expression.
Gene_expression (expression) of dopamine D1 in nucleus accumbens
12) Confidence 0.41 Published 2001 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 11505043 Disease Relevance 0 Pain Relevance 0
Comparative development of D1-dopamine and mu opiate receptors in normal and in 6-hydroxydopamine-lesioned neonatal rat striatum: dopaminergic fibers regulate mu but not D1 receptor distribution.
Gene_expression (distribution) of D1 receptor in striatum associated with dopamine and opiate
13) Confidence 0.41 Published 1991 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 1849802 Disease Relevance 0 Pain Relevance 0.28
Moreover, messenger RNA expression for the dopamine D2 receptor was overall lower than that for the dopamine D1 receptor, both with respect to the level per cell and the number of positive cells within the DARPP-32 patches.
Gene_expression (expression) of dopamine D1 receptor associated with dopamine
14) Confidence 0.40 Published 1995 Journal Neuroscience Section Abstract Doc Link 7708203 Disease Relevance 0 Pain Relevance 0.41
Gene expression studies using real time PCR showed an increased expression of dopamine D1 and D2 receptor in the cerebral cortex of diabetic rats.
Gene_expression (expression) of dopamine D1 in cerebral cortex associated with dopamine, diabetes mellitus and cerebral cortex
15) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.72 Pain Relevance 0.46
Real Time-PCR analysis showed that the dopamine D1 receptor gene expression was significantly increased (p < 0.001) in the cerebral cortex and decreased (p < 0.001) cerebellum in diabetic condition.
Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with dopamine, diabetes mellitus and cerebral cortex
16) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.52 Pain Relevance 0.58
Our study showed that diabetes can regulate the expression of dopamine D1 receptor which may reduce the central cortical function.
Gene_expression (expression) of dopamine D1 receptor associated with dopamine and diabetes mellitus
17) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.82 Pain Relevance 0.49
In our study, curcumin and insulin increased the dopamine D1 receptor expression levels in the cerebellum, which suggests that the curcumin supplementation influenced the functional regulation of these receptors to maintain normal dopaminergic function and this might also be involved as a mechanism of preventing cerebellar dysfunctions.
Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with cerebellar diseases, dopamine and hyperinsulinism
18) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.86 Pain Relevance 0.56
In agreeable with the total dopamine receptor change in the cerebellum dopamine D1 receptor expression was down regulated in the diabetic rats when compared to control.
Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with dopamine, diabetes mellitus and dopamine receptor
19) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.78 Pain Relevance 0.56
Earlier studies suggested that dopamine D1 and mu opioid receptors that regulate adenylyl cyclase are expressed preferentially by striato-nigral neurons, whereas adenosine A2a and delta1 opioid receptors are expressed preferentially by striato-pallidal neurons.
Gene_expression (expressed) of dopamine D1 in neurons associated with adenocard, dopamine, mu opioid receptor and opioid receptor
20) Confidence 0.39 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 0.68

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