INT13335

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Context Info
Confidence 0.34
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.80
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
striatum 2
cortex 2
cerebellum 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 364 100.00 Very High Very High Very High
cerebral cortex 40 100.00 Very High Very High Very High
agonist 18 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
antagonist 38 99.96 Very High Very High Very High
Morphine 8 98.68 Very High Very High Very High
mu opioid receptor 1 94.48 High High
Nucleus accumbens 8 89.96 High High
Pyramidal cell 35 84.16 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 98.92 Very High Very High Very High
Stress 11 93.76 High High
Opiate Addiction 1 58.24 Quite High
Cognitive Disorder 14 57.28 Quite High
Affective Disorder 1 53.12 Quite High
Parkinson's Disease 8 42.72 Quite Low
Targeted Disruption 2 24.84 Low Low
Urological Neuroanatomy 3 23.72 Low Low
Disease 15 20.84 Low Low
Depression 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the relative inhibitory effect of the mu-opioid receptor agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO) on dopamine D1 receptor-stimulated cyclic AMP production was unchanged after exposure to morphine.
Negative_regulation (effect) of Gene_expression (production) of dopamine D1 associated with dopamine, agonist, enkephalin, opioid receptor and morphine
1) Confidence 0.34 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1666051 Disease Relevance 0.06 Pain Relevance 1.15
Real Time-PCR analysis showed that the dopamine D1 receptor gene expression was significantly increased (p < 0.001) in the cerebral cortex and decreased (p < 0.001) cerebellum in diabetic condition.
Negative_regulation (decreased) of Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with dopamine, diabetes mellitus and cerebral cortex
2) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.54 Pain Relevance 0.62
cortex, D1 receptor activation typically inhibits IRKC by direct effects of cAMP on IRK channels, but strong
Negative_regulation (inhibits) of Gene_expression (activation) of D1 receptor in cortex
3) Confidence 0.09 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.18
Indeed, a strong 53% decrease in D1 receptor mRNA expression was observed in the dorsal striatum (0.317±0.0165 for control animals, n?
Negative_regulation (decrease) of Gene_expression ( mRNA expr) of D1 receptor mRNA in striatum
4) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.58
As shown in Fig. 1B, the maximal depolarization caused by SKF83959 (50 µM) in the presence of D1 receptor antagonist SCH23390 (10 µM) was not significantly altered (SCH23390+SKF83959: 5.7±0.5 mV, n?
Negative_regulation (caused) of Gene_expression (presence) of D1 receptor associated with antagonist
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0 Pain Relevance 0.35
2A-adrenoceptor stimulation and moderate levels of D1 receptor stimulation, but impaired by high levels of D1, ?
Negative_regulation (levels) of Gene_expression (stimulation) of D1 receptor
6) Confidence 0.03 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2904493 Disease Relevance 0.20 Pain Relevance 0.28

General Comments

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