INT133374

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pdha1) oxidoreductase activity (Pdha1)
Anatomy Link Frequency
spinal cord 1
amygdala 1
Pdha1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 99.72 Very High Very High Very High
Central nervous system 8 99.16 Very High Very High Very High
pregabalin 18 98.86 Very High Very High Very High
Hippocampus 4 98.68 Very High Very High Very High
amygdala 4 97.68 Very High Very High Very High
Spinal cord 4 97.16 Very High Very High Very High
interstitial cystitis 41 96.56 Very High Very High Very High
Calcium channel 6 75.72 Quite High
diabetic neuropathy 2 61.20 Quite High
Post herpetic neuralgia 2 59.92 Quite High
Disease Link Frequency Relevance Heat
Cystitis 70 99.36 Very High Very High Very High
Interstitial Cystitis 41 96.56 Very High Very High Very High
Epilepsy 2 64.64 Quite High
Partial Seizures 2 64.16 Quite High
Anxiety Disorder 2 62.40 Quite High
Peripheral Neuropathy 2 61.20 Quite High
Diabetes Mellitus 4 60.32 Quite High
Neuralgia 2 59.92 Quite High
Herpes Simplex Virus Infection 2 59.52 Quite High
INFLAMMATION 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this autoradiographic analysis of R217A mice, we show that the mutation to alpha(2)-delta Type 1 substantially reduces specific pregabalin binding in CNS regions that are known to preferentially express the alpha(2)-delta Type 1 protein, notably the neocortex, hippocampus, basolateral amygdala and spinal cord.
Gene_expression (express) of Type 1 in spinal cord associated with pregabalin, hippocampus, central nervous system, amygdala and spinal cord
1) Confidence 0.12 Published 2006 Journal Brain Res. Section Abstract Doc Link 16460711 Disease Relevance 0.43 Pain Relevance 1.32
In this autoradiographic analysis of R217A mice, we show that the mutation to alpha(2)-delta Type 1 substantially reduces specific pregabalin binding in CNS regions that are known to preferentially express the alpha(2)-delta Type 1 protein, notably the neocortex, hippocampus, basolateral amygdala and spinal cord.
Gene_expression (express) of Type 1 in amygdala associated with pregabalin, hippocampus, central nervous system, amygdala and spinal cord
2) Confidence 0.04 Published 2006 Journal Brain Res. Section Abstract Doc Link 16460711 Disease Relevance 0.43 Pain Relevance 1.32
Serum levels of these CXCR3 ligands and local T helper type 1 (Th1) cytokines were also increased.
Gene_expression (levels) of helper type 1 associated with cytokine
3) Confidence 0.02 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.57 Pain Relevance 0.34

General Comments

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