INT133375

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 7
Disease Relevance 3.09
Pain Relevance 7.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pdha1) oxidoreductase activity (Pdha1)
Anatomy Link Frequency
spinal cord 1
neocortex 1
brain 1
amygdala 1
CNS 1
Pdha1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 21 100.00 Very High Very High Very High
pregabalin 63 99.98 Very High Very High Very High
Central nervous system 28 98.92 Very High Very High Very High
Hippocampus 14 98.48 Very High Very High Very High
amygdala 14 97.96 Very High Very High Very High
Spinal cord 14 97.40 Very High Very High Very High
diabetic neuropathy 7 90.32 High High
Post herpetic neuralgia 7 89.68 High High
Disease Link Frequency Relevance Heat
Epilepsy 7 93.76 High High
Partial Seizures 7 93.28 High High
Anxiety Disorder 7 91.52 High High
Peripheral Neuropathy 7 90.32 High High
Herpes Simplex Virus Infection 7 89.48 High High
Diabetes Mellitus 7 89.44 High High
Neuralgia 7 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the distinct localization of alpha(2)-delta Type 1 and mutation-resistant binding (assumed to be alpha(2)-delta Type 2) in brain areas subserving different functions suggests that identification of subunit-specific ligands could further enhance pharmacologic specificity.
Type 1 Binding (binding) of in brain
1) Confidence 0.07 Published 2006 Journal Brain Res. Section Abstract Doc Link 16460711 Disease Relevance 0 Pain Relevance 0.96
In vitro studies have shown that pregabalin binds with high affinity to the alpha(2)-delta (alpha(2)-delta) subunits (Type 1 and 2) of voltage-gated calcium channels.
Type 1 Binding (binds) of associated with pregabalin and calcium channel
2) Confidence 0.05 Published 2006 Journal Brain Res. Section Abstract Doc Link 16460711 Disease Relevance 0.64 Pain Relevance 1.01
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
type 1 Binding (binding) of in neocortex associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
3) Confidence 0.05 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
These findings, in conjunction with prior in vitro binding data, provide evidence that the alpha(2)-delta Type 1 subunit of voltage-gated calcium channels is the major binding protein for pregabalin in CNS.
Type 1 Binding (binding) of in CNS associated with pregabalin, calcium channel and central nervous system
4) Confidence 0.05 Published 2006 Journal Brain Res. Section Abstract Doc Link 16460711 Disease Relevance 0 Pain Relevance 1.12
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
type 1 Binding (binding) of in hippocampus associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
5) Confidence 0.02 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
type 1 Binding (binding) of in amygdala associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
6) Confidence 0.02 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99
Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord: an ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice.
type 1 Binding (binding) of in spinal cord associated with pregabalin, calcium channel, hippocampus, amygdala and spinal cord
7) Confidence 0.02 Published 2006 Journal Brain Res. Section Title Doc Link 16460711 Disease Relevance 0.61 Pain Relevance 0.99

General Comments

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