INT13338

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2005
Negated 1
Speculated 2
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 2.91
Pain Relevance 11.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
neurons 3
SH-SY5Y 2
brain 2
striatum 2
cerebellar granule cells 1
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 50 100.00 Very High Very High Very High
agonist 42 100.00 Very High Very High Very High
antagonist 21 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
MU agonist 2 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 6 99.90 Very High Very High Very High
Arrhythmias 2 Under Development 1 99.08 Very High Very High Very High
Anxiety Disorder 4 99.04 Very High Very High Very High
Stress 10 98.84 Very High Very High Very High
Drug Induced Neurotoxicity 7 98.56 Very High Very High Very High
Congenital Anomalies 1 96.48 Very High Very High Very High
Infarction 3 95.80 Very High Very High Very High
Diabetes Mellitus 8 95.72 Very High Very High Very High
Urological Neuroanatomy 1 73.20 Quite High
Death 1 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sigma receptor regulation of norepinephrine release from rat hippocampal slices.
Regulation (regulation) of Sigma receptor associated with analgesic
1) Confidence 0.57 Published 1995 Journal Brain Res. Section Title Doc Link 7757480 Disease Relevance 0 Pain Relevance 0.71
Effects of sigma receptor activation on voltage-activated K(+) channels and action potential firing were studied in isolated intracardiac neurons using whole-cell patch-clamp recording techniques.
Regulation (Effects) of sigma receptor in neurons associated with action potential
2) Confidence 0.45 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15764734 Disease Relevance 0 Pain Relevance 0.22
We examined the effects of sigma1 receptor agonists against glutamate-induced neurotoxicity in cultured retinal neurons.
Spec (examined) Regulation (effects) of sigma1 receptor in neurons associated with glutamate, drug induced neurotoxicity and agonist
3) Confidence 0.44 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9544798 Disease Relevance 0.31 Pain Relevance 0.32
To further examine the nature of the interaction between sigma receptor ligands and the dopamine transporter, the effects of sigma receptor ligands on amphetamine-stimulated [3H]dopamine release were examined in slices prepared from rat caudate putamen.
Regulation (effects) of sigma receptor in caudate putamen associated with dopamine
4) Confidence 0.43 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652359 Disease Relevance 0 Pain Relevance 0.70
Sigma-receptor regulation of [3H]arachidonic acid release from rat neonatal cerebellar granule cells in culture.
Regulation (regulation) of Sigma-receptor in cerebellar granule cells associated with fortral
5) Confidence 0.43 Published 1994 Journal J. Neurochem. Section Title Doc Link 7931283 Disease Relevance 0 Pain Relevance 0.47
We compare mechanisms by which the prototypical sigma receptor agonist (+)-pentazocine, and the proposed endogenous sigma receptor ligand NPY regulate potassium-stimulated [(3)H]dopamine release from SH-SY5Y cells.
Regulation (regulate) of sigma receptor in SH-SY5Y associated with fortral, dopamine and agonist
6) Confidence 0.43 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986350 Disease Relevance 0 Pain Relevance 0.62
SH-SY5Y cells as a model for sigma receptor regulation of potassium-stimulated dopamine release.
Regulation (regulation) of sigma receptor in SH-SY5Y associated with fortral and dopamine
7) Confidence 0.43 Published 2000 Journal Brain Res. Section Title Doc Link 10986350 Disease Relevance 0 Pain Relevance 0.64
Further evaluation is required to determine whether changes observed in the brain are homogeneous for either or both sigma receptor subtypes as well as potential links between other CNS receptor changes previously observed in STZ-induced diabetic rats.
Spec (whether) Regulation (homogeneous) of sigma receptor in brain associated with diabetes mellitus
8) Confidence 0.43 Published 1999 Journal Life Sci. Section Abstract Doc Link 10622239 Disease Relevance 0.75 Pain Relevance 0.14
The results suggest that the effects of these sigma receptor ligands on contractility and spontaneous contractions are mediated by activation of phospholipase C and elevation of intracellular IP3 level.
Regulation (effects) of sigma receptor
9) Confidence 0.39 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726662 Disease Relevance 0 Pain Relevance 0
Effects of sigma receptor ligands on the extracellular concentration of dopamine in the striatum and prefrontal cortex of the rat.
Regulation (Effects) of sigma receptor in striatum associated with fortral and dopamine
10) Confidence 0.38 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 8608783 Disease Relevance 0 Pain Relevance 0.58
Sigma receptor blockade by BMY 14802 affects enkephalinergic and tachykinin cells differentially in the striatum of the rat.
Regulation (affects) of Sigma receptor in striatum associated with enkephalin
11) Confidence 0.38 Published 1990 Journal Eur. J. Pharmacol. Section Title Doc Link 1968844 Disease Relevance 0 Pain Relevance 0.10
The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
Regulation (affects) of sigma receptor in neurons
12) Confidence 0.38 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0
In the present study, we attempted to clarify the role of sigma 1 receptor subtype in the regulation of DA transmission using a novel and selective sigma 1 receptor agonist, 1-(3,4-dimethoxyphenethyl)-4(3-phenylpropyl)piperazine dihydrochloride (SA4503) in the rat brain.
Regulation (role) of sigma 1 receptor in brain associated with dopamine and agonist
13) Confidence 0.34 Published 1997 Journal Neurochem. Res. Section Abstract Doc Link 9251100 Disease Relevance 0.07 Pain Relevance 0.46
Effects of sigma receptor ligands on conditioned fear stress.
Regulation (Effects) of sigma receptor associated with stress and anxiety disorder
14) Confidence 0.29 Published 1998 Journal Methods Find Exp Clin Pharmacol Section Title Doc Link 9819807 Disease Relevance 0.66 Pain Relevance 0.33
We tested several inhibitors of PKC isozymes, as well as a phospholipase C inhibitor for their effects on sigma1 receptor agonist-mediated regulation of [3H]dopamine release.
Regulation (regulation) of sigma1 receptor associated with dopamine, kinase c and agonist
15) Confidence 0.27 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490613 Disease Relevance 0 Pain Relevance 0.89
Sigma1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C.
Regulation (regulation) of Sigma1 receptor associated with fortral, kinase c, dopamine and agonist
16) Confidence 0.27 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12490613 Disease Relevance 0 Pain Relevance 0.87
Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation.
Regulation (modulation) of sigma-1 receptor associated with convulsion
17) Confidence 0.27 Published 2001 Journal Life Sci. Section Title Doc Link 11488404 Disease Relevance 0.38 Pain Relevance 0.22
Effect of opioid agonists selective for three subclasses of opioid receptors and one sigma receptor agonist on dopamine stimulated adenylate cyclase in rat caudate nucleus.
Regulation (Effect) of sigma receptor in caudate nucleus associated with dopamine, mu agonist, agonist, enkephalin and opioid receptor
18) Confidence 0.24 Published 1991 Journal Pharmacol. Toxicol. Section Title Doc Link 1666431 Disease Relevance 0 Pain Relevance 1.03
In the presence of 10 microM sigma-receptor agonist BD737 or 10 microM sigma-receptor antagonist haloperidol, the distribution and density of [35S]GTPgammaS binding stimulated by 10 nM NPY was not significantly altered.
Neg (not) Regulation (altered) of sigma-receptor associated with antagonist and agonist
19) Confidence 0.24 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.25
These results suggest that CB provides neuroprotection against KA insult via sigma-1 receptor modulation.
Regulation (modulation) of sigma-1 receptor
20) Confidence 0.24 Published 2001 Journal Life Sci. Section Abstract Doc Link 11488404 Disease Relevance 0.30 Pain Relevance 0.20

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