INT133380

Context Info Confidence 0.38 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.10 Pain Relevance 0.89

plasma membrane (ATP1A1) transmembrane transport (ATP1A1)

ATP1A1 (Homo sapiens)

Pain Link Frequency Relevance Heat MU agonist 1 92.48 Enkephalin 2 91.32 Analgesic 12 90.72 corticosteroid 2 89.16 adenocard 1 85.76 Opioid 2 82.80 antagonist 1 40.48 Neuronal excitability 1 34.72 Hyperalgesia 1 25.00 Paracetamol 2 5.00

Disease Link Frequency Relevance Heat Neuroblastoma 1 97.68 Disease 6 5.00 Hypertension 4 5.00 Cancer 4 5.00 Pancytopenia 2 5.00 Overdose 2 5.00 Sunburn 2 5.00 Rheumatic Diseases 2 5.00 Chronic Disease 2 5.00 Hyperalgesia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, Metildigoxin (D02587) is predicted to have an interaction with a human Na+/K+ transporting ATPase (ATP1A1), based on the reported interaction of digoxin (D00298).

ATP1A1 Binding (interaction) of

1) Confidence 0.38 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0 Pain Relevance 0.26

Prostaglandin E1 (1 microM) transiently inhibited Na,K-ATPase activity for 10-15 min.

Na,K-ATPase Binding (activity) of

2) Confidence 0.29 Published 2006 Journal Life Sci. Section Abstract Doc Link 16460765 Disease Relevance 0.10 Pain Relevance 0.38

For example, Metildigoxin (D02587) is predicted to have an interaction with a human Na+/K+ transporting ATPase (ATP1A1), based on the reported interaction of digoxin (D00298).

ATP1A1 Binding (interaction) of

3) Confidence 0.28 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0 Pain Relevance 0.25

General Comments

This test has worked.