INT1334

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 29
Total Number 30
Disease Relevance 3.03
Pain Relevance 20.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 6
dorsal 4
hippocampus 4
basal ganglia 4
cardiac muscle 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 80 100.00 Very High Very High Very High
orphanin 24 100.00 Very High Very High Very High
Enkephalin 24 100.00 Very High Very High Very High
agonist 22 100.00 Very High Very High Very High
antagonist 19 100.00 Very High Very High Very High
Opioid 14 100.00 Very High Very High Very High
Spinal cord 11 100.00 Very High Very High Very High
dorsal rhizotomy 6 99.82 Very High Very High Very High
Morphine 19 99.80 Very High Very High Very High
Immobilon 5 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 3 100.00 Very High Very High Very High
Anxiety Disorder 2 100.00 Very High Very High Very High
Volume Depletion And Dehydration 4 99.98 Very High Very High Very High
Bordatella Infection 2 99.66 Very High Very High Very High
Stress 8 99.24 Very High Very High Very High
Pain 3 96.56 Very High Very High Very High
Aggression 1 92.36 High High
Glioma 3 90.64 High High
Neuroblastoma 3 90.36 High High
Diabetes Insipidus 1 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endogenous concentrations of zinc ions in the hippocampus, the cerebral cortex and the basal ganglia are compatible with the concentrations needed to inhibit opiate receptor binding in vitro.
Negative_regulation (inhibit) of opiate receptor Binding (binding) of in basal ganglia associated with opiate, hippocampus and cerebral cortex
1) Confidence 0.59 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6283789 Disease Relevance 0 Pain Relevance 0.85
The factor inhibited binding to the opiate receptor in synaptic plasma membranes of rat brain and to the receptor of the guinea-pig ileum although it was less effective on the latter, particularly after long-term incubation.
Negative_regulation (inhibited) of opiate receptor Binding (binding) of in ileum associated with opiate
2) Confidence 0.59 Published 1975 Journal Acta Physiol. Scand. Section Abstract Doc Link 1155169 Disease Relevance 0 Pain Relevance 0.25
Dehydration reduces kappa-opiate receptor binding in the neurohypophysis of the rat.
Negative_regulation (reduces) of kappa-opiate receptor Binding (binding) of in neurohypophysis associated with volume depletion and dehydration and opiate
3) Confidence 0.59 Published 1987 Journal Brain Res. Section Title Doc Link 2827842 Disease Relevance 0.44 Pain Relevance 0.32
Opiate receptor binding in the spinal cord is reduced acutely by about 22% and remains slightly depressed into adulthood.
Negative_regulation (reduced) of Opiate receptor Binding (binding) of in spinal cord associated with opiate and spinal cord
4) Confidence 0.57 Published 1982 Journal Dev. Neurosci. Section Abstract Doc Link 6186451 Disease Relevance 0 Pain Relevance 0.68
A uniform decrease of opiate receptor binding was found throughout the dorsal dentate gyrus, while a more localized decrease of these sites occurred in hilar and granular layers of the ventral dentate gyrus.
Negative_regulation (decrease) of opiate receptor Binding (binding) of in dorsal associated with opiate
5) Confidence 0.54 Published 1996 Journal Brain Res. Section Abstract Doc Link 8866710 Disease Relevance 0 Pain Relevance 0.92
1-Alkyl-4,4-diphenylpiperidines inhibit the binding of mu- and delta-opiate receptor agonists to crude synaptosomal membranes of rat brain.
Negative_regulation (inhibit) of opiate receptor Binding (binding) of in brain associated with agonist and opiate
6) Confidence 0.47 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6301858 Disease Relevance 0 Pain Relevance 0.56
It appears that chronic morphine treatment decreases the affinity of the opiate receptor for morphine.
Negative_regulation (decreases) of opiate receptor Binding (affinity) of associated with opiate and morphine
7) Confidence 0.43 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197922 Disease Relevance 0 Pain Relevance 1.77
Zinc ions can totally block stereospecific binding of 3H-met-enkephalinamide (2-D-ala-5-L-methionine) to opiate receptor sites in synaptic membranes of the hippocampus, the cerebral cortex and the basal ganglia of the rat brain.
Negative_regulation (block) of opiate receptor Binding (binding) of in basal ganglia associated with hippocampus, opiate and cerebral cortex
8) Confidence 0.43 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 6283789 Disease Relevance 0 Pain Relevance 0.57
The diffuse distribution of ORL1 mRNA and binding supports an extensive role for orphanin FQ in a multitude of CNS functions, including motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression, and autonomic control of physiologic processes.
Negative_regulation (distribution) of ORL1 mRNA Binding (binding) of in CNS associated with stress, nociception, orphanin, aggression and central nervous system
9) Confidence 0.42 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464356 Disease Relevance 0.28 Pain Relevance 0.88
An endogenous inhibitor of N-methyltransferase activity and opiate receptor binding in rabbit tissue.
Negative_regulation (inhibitor) of opiate receptor Binding (binding) of associated with opiate and immobilon
10) Confidence 0.39 Published 1976 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 189325 Disease Relevance 0 Pain Relevance 0.24
Inhibition of opiate receptor binding by zinc ions: possible physiological importance in the hippocampus.
Negative_regulation (Inhibition) of opiate receptor Binding (binding) of in hippocampus associated with hippocampus and opiate
11) Confidence 0.38 Published 1981 Journal Peptides Section Title Doc Link 6267559 Disease Relevance 0 Pain Relevance 0.73
Injection of the (1-13) fragment into rat hippocampus had no effect on spatial learning or motor function under conditions where nociceptin is active, showing that this metabolic conversion reduces affinity for the ORL-1-receptor.
Negative_regulation (reduces) of ORL-1-receptor Binding (affinity) of in hippocampus associated with orphanin and hippocampus
12) Confidence 0.38 Published 1999 Journal Neuroreport Section Abstract Doc Link 10094136 Disease Relevance 0 Pain Relevance 0.43
The specific binding of 3H-lofentanil to delta-opiate receptor subtype was down-regulated (decrease in Bmax value without change in the KD value) after prolonged incubation of the cells in the presence of leu- and met- enkephalin (0.1 microM).
Negative_regulation (down-regulated) of delta-opiate receptor Binding (binding) of associated with enkephalin and opiate
13) Confidence 0.38 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2566925 Disease Relevance 0.18 Pain Relevance 0.76
Transplants of embryonic striatum to cavities in the cortex of young adult hosts developed diffuse opiate receptor binding but not dopamine receptor binding.
Negative_regulation (developed) of opiate receptor Binding (binding) of in cavities associated with dopamine receptor and opiate
14) Confidence 0.37 Published 1986 Journal Brain Res. Section Abstract Doc Link 3011213 Disease Relevance 0 Pain Relevance 0.52
These effects were not mediated through direct interaction with opioid-binding sites, since receptor-binding assays using rat brain membranes confirmed that clonixinate up to 1 x 10(-4) mol/l does not inhibit mu, delta, and kappa receptor specific binding.
Negative_regulation (inhibit) of kappa receptor Binding (binding) of in brain associated with opioid
15) Confidence 0.34 Published 1999 Journal Pharmacology Section Abstract Doc Link 10077738 Disease Relevance 0.15 Pain Relevance 0.65
In vitro studies have shown that [Phe1Psi(CH2-NH)Gly2]OFQ/N(1-13)-NH2 (referred to as [FG]OFQ/N(1-13)-NH2) is the first selective antagonist to prevent the binding of the endogenous ligand orphanin FQ/Nociceptin (OFQ/N) at the orphan opioid-like receptor.
Negative_regulation (prevent) of orphan opioid-like receptor Binding (binding) of associated with orphanin, antagonist and opioid
16) Confidence 0.33 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087001 Disease Relevance 0.07 Pain Relevance 0.36
[Processes of protein biosynthesis in cardiac muscle and cardioprotective effect of mu-opiate receptor ligands in immobilization stress].
Negative_regulation (effect) of mu-opiate receptor Binding (ligands) of in cardiac muscle associated with stress and opiate
17) Confidence 0.33 Published 2000 Journal Vopr. Med. Khim. Section Title Doc Link 10885032 Disease Relevance 0.45 Pain Relevance 0.18
Administration of buprenorphine to rats produced a long-lasting (>24 h) decrease in mu and kappa2 receptor binding and attenuated mu-stimulated [(35)S]-GTP-gamma-S binding.
Negative_regulation (decrease) of kappa2 receptor Binding (binding) of associated with buprenorphine
18) Confidence 0.30 Published 1999 Journal Synapse Section Abstract Doc Link 10502307 Disease Relevance 0 Pain Relevance 1.21
The role of the opioid-like receptor 1 (ORL1) and its endogenous ligand, nociceptin/orphanin FQ (N/OFQ), in nociception, anxiety, and learning remains to be defined.
Negative_regulation (defined) of ORL1 Binding (role) of associated with nociception, orphanin, anxiety disorder and opioid
19) Confidence 0.29 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419552 Disease Relevance 0.20 Pain Relevance 0.54
The role of the opioid-like receptor 1 (ORL1) and its endogenous ligand, nociceptin/orphanin FQ (N/OFQ), in nociception, anxiety, and learning remains to be defined.
Negative_regulation (defined) of opioid-like receptor 1 Binding (role) of associated with nociception, orphanin, anxiety disorder and opioid
20) Confidence 0.29 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419552 Disease Relevance 0.20 Pain Relevance 0.54

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