INT133423

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.51
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Micrl (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 30 99.98 Very High Very High Very High
Inflammatory marker 6 68.84 Quite High
cytokine 6 65.96 Quite High
Inflammation 18 63.44 Quite High
topical agent 6 53.84 Quite High
spinal inflammation 4 50.00 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 198 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 102 98.56 Very High Very High Very High
Toxicity 84 98.12 Very High Very High Very High
Herpes Simplex Virus Infection 18 74.32 Quite High
INFLAMMATION 24 68.52 Quite High
Infection 84 57.80 Quite High
Low Back Pain 4 50.00 Quite Low
Congenital Anomalies 6 24.04 Low Low
Disease 7 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The estimated cost-increase per unit-increase in the BASFI score at values < 5 was around 1,000 Canadian dollars, and more than 5,000 Canadian dollars at values > 7.
Positive_regulation (increase) of cost-increase
1) Confidence 0.18 Published 2006 Journal J. Rheumatol. Section Body Doc Link 16465660 Disease Relevance 0 Pain Relevance 0
Thirty percent glycerin caused a significant increase in HSV-2 susceptibility in our model.


Positive_regulation (caused) of increase associated with cold sores
2) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2996397 Disease Relevance 0.67 Pain Relevance 0
Moreover, consistent with the reports of toxicity with the extremely hyperosmotic formulations cited, we found that an extremely hyperosmotic vehicle, KYWJ (osmolality > 10,000 mOsm/kg) caused a 7-fold increase in susceptibility to HSV-2 (Table 2).
Positive_regulation (caused) of increase associated with toxicity and cold sores
3) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2996397 Disease Relevance 0.46 Pain Relevance 0
We found that a single exposures to the candidate microbicides nonoxynol-9 and C31G caused a marked increase in susceptibility to HSV-2, concordant with the increased susceptibility to HIV with nonoxynol-9 observed in a Phase III clinical microbicide trial [2], and a trend toward increased transmission in a Phase III trial of C31G [3].
Positive_regulation (caused) of increase associated with cold sores and acquired immune deficiency syndrome or hiv infection
4) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2996397 Disease Relevance 0.76 Pain Relevance 0.16
In our studies, the moderately hyperosmotic formulations of 10% glycerin and 10% propylene glycol did not show a significant increase in susceptibility, though 10% glycerin showed a trend toward, and 30% glycerin caused a significant increase in susceptibility.
Positive_regulation (caused) of increase
5) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2996397 Disease Relevance 0.36 Pain Relevance 0
An intermediate concentration of another humectant/solvent, 30% glycerin in HEC also caused a significant increase in susceptibility.
Positive_regulation (caused) of increase
6) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2996397 Disease Relevance 0.05 Pain Relevance 0.03
However, neither parabens nor benzyl alcohol caused a detectable increase in susceptibility in our model, despite an apparent association of benzyl alcohol with irritative symptoms in a Phase I study of cellulose sulfate [24].
Neg (neither) Positive_regulation (caused) of increase associated with alcohol
7) Confidence 0.01 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2996397 Disease Relevance 0.21 Pain Relevance 0.10

General Comments

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