INT13344

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Context Info
Confidence 0.02
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) intracellular (Adarb1) extracellular space (Npy)
extracellular region (Npy) RNA binding (Adarb1) nucleolus (Adarb1)
Anatomy Link Frequency
pituitary 1
Npy (Rattus norvegicus)
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 100.00 Very High Very High Very High
Dopamine 4 97.72 Very High Very High Very High
Nucleus accumbens 3 96.68 Very High Very High Very High
agonist 1 81.44 Quite High
fortral 4 80.56 Quite High
antagonist 5 76.48 Quite High
narcan 2 46.80 Quite Low
Opioid 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Psychosis 2 99.20 Very High Very High Very High
Stress 5 95.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropeptide Y (NPY) has been named as a possible endogenous ligand for a subpopulation of sigma receptors on the basis of its ability to compete for sigma receptor binding.
Neuropeptide Y Binding (ligand) of receptors associated with neuropeptide
1) Confidence 0.02 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454797 Disease Relevance 0.10 Pain Relevance 0.69
Following a series of investigations supporting the concept that the brain stem catecholaminergic (CA) system played a major stimulatory role on both basal and stress-triggered states of the hypothalamic-pituitary-adrenocortical (HPA) axis, across alpha 1 and beta receptors and also via alpha 2 receptors, the present study was designed to gain a deeper insight into the fine mechanism of functional interactions between the alpha 2 receptors mediated CA system and two peptidergic mechanisms, both shown to take part in the stimulatory control of the HPA axis: beta-endorphin and NPY.
NPY Binding (interactions) of receptors in pituitary associated with stress
2) Confidence 0.01 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1666688 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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