INT133441

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.01
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal horn 4
projection neurons 2
RVM 2
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 243 100.00 Very High Very High Very High
Hyperalgesia 30 100.00 Very High Very High Very High
Dorsal horn 27 99.98 Very High Very High Very High
projection neuron 21 99.50 Very High Very High Very High
antagonist 7 99.50 Very High Very High Very High
Neuropathic pain 48 98.28 Very High Very High Very High
Serotonin 7 96.82 Very High Very High Very High
Glutamate receptor 4 92.72 High High
substantia gelatinosa 7 90.68 High High
Glutamate 2 86.96 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 159 100.00 Very High Very High Very High
Hyperalgesia 33 100.00 Very High Very High Very High
Neuropathic Pain 57 98.28 Very High Very High Very High
Hypersensitivity 21 97.88 Very High Very High Very High
INFLAMMATION 27 82.12 Quite High
Injury 12 75.00 Quite High
Pain 45 74.52 Quite High
Nociception 13 70.96 Quite High
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Amputation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin receptor antagonists were unexpectedly without effect, but a GABAA receptor antagonist, bicuculline, or a glycine receptor antagonist, strychnine, completely suppressed the RVM stimulation-induced increase in IPSCs.
Negative_regulation (suppressed) of Positive_regulation (increase) of RVM in RVM associated with antagonist, serotonin and rostral ventromedial medulla
1) Confidence 0.28 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16467527 Disease Relevance 0.07 Pain Relevance 1.37
We therefore hypothesized that the loss of mechanical hypersensitivity in neuropathic pain states following ablation of lamina I/III projection neurons would be accompanied by reduced ERK activation in the RVM.
Negative_regulation (reduced) of Positive_regulation (activation) of RVM in projection neurons associated with hypersensitivity, neuropathic pain, projection neuron and rostral ventromedial medulla
2) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.88 Pain Relevance 0.96
First, we showed that lesions of the lamina I/III ascending pathway from the dorsal horn attenuated both mechanical hyperalgesia and ERK activation in the RVM.
Negative_regulation (attenuated) of Positive_regulation (activation) of RVM in dorsal horn associated with hyperalgesia, dorsal horn and rostral ventromedial medulla
3) Confidence 0.16 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2945971 Disease Relevance 1.13 Pain Relevance 0.83
Ablation of NK1 receptor expressing neurones in the dorsal horn reduces the expression of SNI induced pERK in the RVM
Negative_regulation (reduces) of Positive_regulation (induced) of RVM in dorsal horn associated with nervous system injury, dorsal horn and rostral ventromedial medulla
4) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.93 Pain Relevance 0.36

General Comments

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