INT133443

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.48
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Mmp2) cytoplasm (Mmp2) extracellular space (Mmp2)
peptidase activity (Mmp2) extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2)
Anatomy Link Frequency
striatum 2
muscle 1
hippocampus 1
Mmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 181 100.00 Very High Very High Very High
Hippocampus 15 97.52 Very High Very High Very High
antidepressant 9 96.20 Very High Very High Very High
Desipramine 1 85.48 High High
anesthesia 8 84.20 Quite High
fluoxetine 1 84.12 Quite High
fibrosis 42 69.52 Quite High
Dismenorea 1 50.00 Quite Low
Inflammation 27 35.20 Quite Low
alcohol 1 11.84 Low Low
Disease Link Frequency Relevance Heat
Cancer 87 97.36 Very High Very High Very High
Endometriosis (extended) 2 88.92 High High
Brain Hemorrhage 2 85.64 High High
Neurodegenerative Disease 7 83.64 Quite High
Convulsion 3 83.64 Quite High
Fibrosis 28 79.12 Quite High
Necrosis 1 77.96 Quite High
Glioma 48 77.44 Quite High
Body Weight 6 56.96 Quite High
Hypoxia 78 54.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative analysis and localization of mRNA transcripts of type I collagen, osteocalcin, MMP 2, MMP 8, and MMP 13 during bone healing in a rat calvarial experimental defect model.
Transcription (transcripts) of MMP 2
1) Confidence 0.69 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.31
We observed that acute and chronic ECS differentially regulate the transcript levels of MMP-2/9 and TIMPs 1-4 and also increase gelatinase activity in the hippocampus.
Transcription (levels) of MMP-2 in hippocampus associated with hippocampus
2) Confidence 0.53 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.14 Pain Relevance 0.80
The abundance of MMP2 mRNA was similar in all tissues and there was a significant age-dependent decrease in MMP2 mRNA in the SAN head and atrial muscle at least (Fig. 7A).
Transcription (abundance) of MMP2 mRNA in muscle
3) Confidence 0.43 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.38 Pain Relevance 0.18
to measure the activity of MMP-2 and MMP-9 by zymography.


Transcription (activity) of MMP-2 associated with metalloproteinase
4) Confidence 0.42 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.11 Pain Relevance 0.20
GLA infusion was associated with a decrease in MMP2 (35 ± 6.8%) mRNA expression (Figure 2A).
Transcription (expression) of MMP2
5) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.51 Pain Relevance 0
Expression of ERK1/2 was also reduced by 27 ± 7.7% and 31 ± 8.7% respectively. mRNA expression of matrix metalloproteinase-2 (MMP2) was reduced by 35 ± 6.8% and zymography showed MMP2 proteolytic activity was reduced by 32 ± 8.5%.
Transcription (expression) of MMP2 associated with metalloproteinase
6) Confidence 0.31 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.61 Pain Relevance 0.05
The increase in net gelatinolytic activity found in the striatum of groups receiving supplementary oxygen for resuscitation stands in contrast to the decrease of MMP-9 and preservation of MMP-2 mRNA levels found in these experimental groups.
Transcription (levels) of MMP-2 in striatum
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.28 Pain Relevance 0.04
The increase in net gelatinolytic activity found in the striatum of groups receiving supplementary oxygen for resuscitation stands in contrast to the decrease of MMP-9 and preservation of MMP-2 mRNA levels found in these experimental groups.
Transcription (found) of MMP-2 in striatum
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.28 Pain Relevance 0.04
The real-time PCR technique was applied to detected the mRNA expressions of MMP-2, MMP-3 and TIMP-2.
Transcription (expressions) of MMP-2
9) Confidence 0.19 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.18 Pain Relevance 0

General Comments

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