INT13347

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 6
Disease Relevance 0.64
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 28 100.00 Very High Very High Very High
Kinase C 23 100.00 Very High Very High Very High
narcan 16 100.00 Very High Very High Very High
opiate 7 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
Opioid 12 98.88 Very High Very High Very High
Morphine 2 97.92 Very High Very High Very High
Delta opioid receptors 1 80.48 Quite High
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 7 98.04 Very High Very High Very High
Hyperinsulinism 2 93.12 High High
Neuroblastoma 3 66.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been revealed that a deficiency in the MOR gene (Oprm1) or a difference in the 3' noncoding region of the gene markedly affects the sensitivity of mice to opioids.
Regulation (affects) of Negative_regulation (deficiency) of MOR gene associated with opioid receptor and opioid
1) Confidence 0.45 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.52
It has been revealed that a deficiency in the MOR gene (Oprm1) or a difference in the 3' noncoding region of the gene markedly affects the sensitivity of mice to opioids.
Regulation (affects) of Negative_regulation (deficiency) of Oprm1 associated with opioid receptor and opioid
2) Confidence 0.45 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.52
Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor.
Regulation (affect) of Negative_regulation (desensitization) of mu-opioid receptor associated with agonist and opioid receptor
3) Confidence 0.26 Published 2000 Journal Mol. Pharmacol. Section Title Doc Link 10908307 Disease Relevance 0 Pain Relevance 0.37
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II.
Regulation (Role) of Negative_regulation (regulation) of mu-opioid receptor associated with kinase c, analgesic, agonist and opioid receptor
4) Confidence 0.07 Published 1999 Journal J. Neurochem. Section Title Doc Link 9930731 Disease Relevance 0.07 Pain Relevance 1.18
The effect of opiate receptor blockade on human CRH-induced PRL secretion was examined in ovariectomized and normal female rhesus monkeys.
Regulation (effect) of Negative_regulation (blockade) of opiate receptor associated with opiate
5) Confidence 0.04 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2542355 Disease Relevance 0 Pain Relevance 0.17
Effect of opiate receptor blockade on the insulin response to oral glucose load in polycystic ovarian disease.
Regulation (Effect) of Negative_regulation (blockade) of opiate receptor associated with narcan, polycystic ovary syndrome and opiate
6) Confidence 0.01 Published 1991 Journal Hum. Reprod. Section Title Doc Link 1666896 Disease Relevance 0.58 Pain Relevance 0.62

General Comments

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