INT13348

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Context Info
Confidence 0.36
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.33
Pain Relevance 7.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
neuronal 1
spinal 1
plasma 1
tail 1
brain 1
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 17 100.00 Very High Very High Very High
analgesia 32 99.96 Very High Very High Very High
antagonist 27 99.70 Very High Very High Very High
Eae 13 99.00 Very High Very High Very High
Cannabinoid receptor 21 98.88 Very High Very High Very High
Pain 11 98.60 Very High Very High Very High
Dynorphin 4 98.32 Very High Very High Very High
Cannabinoid 112 98.06 Very High Very High Very High
antinociception 5 97.60 Very High Very High Very High
adenocard 5 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 10 98.60 Very High Very High Very High
Convulsion 4 98.24 Very High Very High Very High
Catalepsy 31 97.40 Very High Very High Very High
Psychosis 2 96.88 Very High Very High Very High
Sprains And Strains 7 92.24 High High
Nicotine Addiction 1 91.72 High High
Targeted Disruption 17 91.28 High High
Sleep Disorders 4 91.28 High High
Cognitive Disorder 5 90.96 High High
Neurodegenerative Disease 83 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion.
Negative_regulation (reduction) of THC in spinal associated with dynorphin, delta-9-tetrahydrocannabinol and analgesia
1) Confidence 0.36 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11717384 Disease Relevance 0 Pain Relevance 0.82
No synergism was detected either in the production of antinociception (tail flick test) or in a test in which the ability of flurazepam to delay onset of clonic convulsions induced by intravenous infusion of pentylenetetrazole was compared in the presence and absence of THC or cannabidiol.
Negative_regulation (absence) of THC in tail associated with antinociception, convulsion, delta-9-tetrahydrocannabinol and tail-flick
2) Confidence 0.24 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1666920 Disease Relevance 0.27 Pain Relevance 0.79
A significant reduction of THC-induced rewarding and aversive effects was found in mice lacking A2A adenosine receptors in comparison with wild-type littermates.
Negative_regulation (reduction) of THC associated with adenocard
3) Confidence 0.19 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15450100 Disease Relevance 0.48 Pain Relevance 0.55
The psychoactive effects of cannabinoids are mediated by the cannabinoid receptor type 1 (CB1) and, in particular, the tetrad effects of THC are abolished in mutant mice lacking the expression of CB1 [6,7] and are blocked by CB1 antagonists [5,8,9].
Negative_regulation (abolished) of THC associated with cannabinoid receptor, antagonist and cannabinoid
4) Confidence 0.16 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.15 Pain Relevance 0.56
The vanilloid receptor antagonist ruthenium red abolishes the responses to THC and cannabinol.
Negative_regulation (abolishes) of THC associated with antagonist
5) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040079 Disease Relevance 0.35 Pain Relevance 0.85
Cataleptic effects of THC are impaired both in CaMK-CB1?
Negative_regulation (impaired) of THC
6) Confidence 0.12 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.50 Pain Relevance 0.68
The effects of AEA, unlike THC, were not decreased in CB(1)-/- mice.
Neg (not) Negative_regulation (decreased) of THC
7) Confidence 0.08 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11080195 Disease Relevance 0.30 Pain Relevance 0.36
TRH or HPD pretreatment had no effect on the distribution of total radioactivity representing THC and its metabolites in brain and plasma.
Negative_regulation (representing) of THC in plasma
8) Confidence 0.05 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6258926 Disease Relevance 0.16 Pain Relevance 1.01
A study by Boucher et al. has shown that THC impaired spatial memory and reversal learning, even in animals that received a THC pretreatment, indicating that although tolerance to the effects of THC on neuronal activity in the prefrontal cortex was reported, cannabinoid-induced memory impairment in these animals persisted [7].
Negative_regulation (impaired) of THC in neuronal associated with cognitive disorder, cannabinoid and tolerance
9) Confidence 0.05 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.82 Pain Relevance 0.31
In contrast, a significant Delta(9)-THC-induced decrease of body temperature and locomotor activity was only observed in WT, but not in nNOS-KO mice.
Negative_regulation (decrease) of THC in body associated with eae
10) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11168564 Disease Relevance 0.14 Pain Relevance 0.33
TRH or HPD pretreatment had no effect on the distribution of total radioactivity representing THC and its metabolites in brain and plasma.
Negative_regulation (representing) of THC in brain
11) Confidence 0.02 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6258926 Disease Relevance 0.16 Pain Relevance 1.01

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