INT133481

Context Info Confidence 0.13 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0.09

plasma membrane (TNF, PTEN) intracellular (TNF) enzyme binding (PTEN) extracellular matrix organization (TNF) lipid metabolic process (PTEN) cytoplasm (PTEN)

Anatomy Link Frequency SK-N-SH 2 TNF (Homo sapiens) PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 1 71.84 Restless leg syndrome 1 55.32

Disease Link Frequency Relevance Heat Apoptosis 2 99.80 Death 1 99.20 Neuroblastoma 1 88.52 Cv Unclassified Under Development 1 71.84 Cv General 4 Under Development 1 69.96 Stroke 1 56.16 Increased Venous Pressure Under Development 1 55.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, cilostazol prevented TNF-alpha-induced PTEN phosphorylation and apoptotic cell death via increased CK2 phosphorylation in the SK-N-SH cells.

TNF-alpha Positive_regulation (induced) of Phosphorylation (phosphorylation) of PTEN in SK-N-SH associated with apoptosis and death

1) Confidence 0.13 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.61 Pain Relevance 0.09

General Comments

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