INT133482

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) plasma membrane (KCNMA1) nucleus (CREB1)
CREB1 (Homo sapiens)
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 59.52 Quite High
Restless leg syndrome 1 43.00 Quite Low
Disease Link Frequency Relevance Heat
Death 1 90.20 High High
Apoptosis 2 89.76 High High
Neuroblastoma 1 76.20 Quite High
Cv Unclassified Under Development 1 59.52 Quite High
Cv General 4 Under Development 1 57.64 Quite High
Stroke 1 43.84 Quite Low
Increased Venous Pressure Under Development 1 43.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it was suggested that the action of cilostazol to promote cell survival was ascribed to the maxi-K channel opening-coupled upregulation of CK2 phosphorylation and downregulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB.
CREB Positive_regulation (upregulation) of channel
1) Confidence 0.01 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

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