INT133484

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.77
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYCS) transport (CYCS) mitochondrion (CYCS)
small molecule metabolic process (CYCS) nucleus (CYCS)
Anatomy Link Frequency
endothelial cells 2
CYCS (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 93.64 High High
cytokine 4 90.92 High High
cINOD 9 81.24 Quite High
Restless leg syndrome 1 77.12 Quite High
COX-2 inhibitor 1 50.00 Quite Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 35 98.52 Very High Very High Very High
Shock 1 94.84 High High
Cv Unclassified Under Development 1 93.64 High High
Cv General 4 Under Development 1 91.76 High High
Neuroblastoma 1 84.24 Quite High
Aggression 2 80.00 Quite High
Cancer 17 79.40 Quite High
Stroke 1 77.96 Quite High
Stress 3 77.80 Quite High
Increased Venous Pressure Under Development 1 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increase in cyclic AMP and decrease in TNF-alpha levels were identified in the ipsilateral cortex under treatment with cilostazol accompanied by decreased Bax formation and cytochrome c release with increased Bcl-2 production in the penumbral area as well as in the in vitro human umbilical endothelial cells.
Negative_regulation (decreased) of Localization (release) of cytochrome c in endothelial cells
1) Confidence 0.42 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.62 Pain Relevance 0.12
Moreover, melatonin reduces indomethacin-mediated activation of caspase-9 and caspase-3 by blocking the release of cytochrome c and finally rescues gastric mucosal cells from indomethacin-induced apoptosis as measured by the TUNEL assay.
Negative_regulation (blocking) of Localization (release) of cytochrome c associated with apoptosis
2) Confidence 0.42 Published 2009 Journal J. Pineal Res. Section Abstract Doc Link 19220725 Disease Relevance 0.96 Pain Relevance 0.40
Akt also blocks cytochrome C release from the mitochondria through the regulation of Bcl-2 [31] and regulates expression of cIAP-1 [32].
Negative_regulation (blocks) of Localization (release) of cytochrome C
3) Confidence 0.42 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 1.06 Pain Relevance 0.17
CONCLUSION: One of the pathways involved in SC-236-induced apoptosis in gastric cancer cells is through downregulation of Akt and then release of cytochrome c.


Negative_regulation (downregulation) of Localization (release) of cytochrome c
4) Confidence 0.41 Published 2006 Journal Digestion Section Body Doc Link 16641552 Disease Relevance 0.12 Pain Relevance 0

General Comments

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