INT133488

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN)
plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)
Anatomy Link Frequency
SK-N-SH 4
PTEN (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 3 80.56 Quite High
cytokine 4 79.92 Quite High
Restless leg syndrome 3 64.04 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 27 99.80 Very High Very High Very High
Death 4 99.20 Very High Very High Very High
Neuroblastoma 3 98.62 Very High Very High Very High
Endometrial Cancer 20 94.16 High High
Cv Unclassified Under Development 3 80.56 Quite High
Cv General 4 Under Development 3 78.68 Quite High
Stroke 3 64.88 Quite High
Increased Venous Pressure Under Development 3 64.04 Quite High
Cancer 16 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it was suggested that the action of cilostazol to promote cell survival was ascribed to the maxi-K channel opening-coupled upregulation of CK2 phosphorylation and downregulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB.
Negative_regulation (downregulation) of Phosphorylation (phosphorylation) of PTEN
1) Confidence 0.41 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.36 Pain Relevance 0.03
Further, cilostazol prevented TNF-alpha-induced PTEN phosphorylation and apoptotic cell death via increased CK2 phosphorylation in the SK-N-SH cells.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of PTEN in SK-N-SH associated with apoptosis and death
2) Confidence 0.41 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.61 Pain Relevance 0.09
Cilostazol suppressed TNF-alpha-induced decrease in viability of SK-N-SH (human neuroblastoma) cells and HCN-1A (human cortical neuron) cells in association with decrease in PTEN phosphorylation and increase in Akt/CREB phosphorylation with suppression of DNA fragmentation, all of which were antagonized by iberiotoxin, a maxi-K(+) channel blocker.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of PTEN in SK-N-SH associated with neuroblastoma
3) Confidence 0.41 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 16472148 Disease Relevance 0.62 Pain Relevance 0.10
PTEN is a crucial phosphatase involved in the regulation of Akt phosphorylation: the presence of an active PTEN protein blocks Akt phosphorylation by the dephosphorylation of PI 3-K product, PIP3 [45].
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of PTEN
4) Confidence 0.30 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox