INT1335

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 123
Total Number 124
Disease Relevance 18.02
Pain Relevance 77.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
NG108-15 7
brain 6
neurons 5
Respiratory 2
plasma 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 239 100.00 Very High Very High Very High
orphanin 135 100.00 Very High Very High Very High
agonist 131 100.00 Very High Very High Very High
opioid receptor 99 100.00 Very High Very High Very High
Opioid 95 100.00 Very High Very High Very High
antagonist 81 100.00 Very High Very High Very High
Kappa opioid receptor 62 100.00 Very High Very High Very High
Immobilon 54 100.00 Very High Very High Very High
medulla 21 100.00 Very High Very High Very High
Opioid receptor 1 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 15 100.00 Very High Very High Very High
Respiratory Failure 5 99.96 Very High Very High Very High
Hypertension 13 99.92 Very High Very High Very High
Insulin Resistance 4 99.92 Very High Very High Very High
Neuroblastoma 20 99.84 Very High Very High Very High
Stress 18 99.82 Very High Very High Very High
Polycystic Ovary Syndrome 6 99.68 Very High Very High Very High
Encephalopathy 5 99.62 Very High Very High Very High
Hyperinsulinism 4 99.46 Very High Very High Very High
Glioma 20 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coronal diencephalic hemisections, but not decortications, in the early postnatal period produced drastic shrinkage of the striatum and, more importantly, a large decrease in opiate receptor patches when expressed as a proportion of total striatal area.
Negative_regulation (decrease) of opiate receptor in striatum associated with opiate
1) Confidence 0.59 Published 1986 Journal Brain Res. Section Abstract Doc Link 3011213 Disease Relevance 0 Pain Relevance 0.38
Conversely, blockade of the opiate receptor with naloxone did not alter elevated BP in cases of established hypertension (spontaneously hypertensive rats, deoxycorticosterone (DOCA)-salt rats and long-term isolated rats).
Negative_regulation (blockade) of opiate receptor associated with hypertension, narcan and opiate
2) Confidence 0.59 Published 1987 Journal Life Sci. Section Abstract Doc Link 3683083 Disease Relevance 0.68 Pain Relevance 0.57
Continued presence of these substances in turn results in a decrease in opiate receptor density and may account for the development of tolerance to the analgesic action of nitrous oxide.
Negative_regulation (decrease) of opiate receptor associated with analgesic, tolerance and opiate
3) Confidence 0.59 Published 1982 Journal Anesthesiology Section Abstract Doc Link 6283950 Disease Relevance 0 Pain Relevance 0.92
The kappa receptor densities were generally decreased, while both the mu and the opioid receptor-like 1 receptors were up-regulated.
Negative_regulation (decreased) of kappa receptor associated with opioid receptor
4) Confidence 0.58 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834892 Disease Relevance 0 Pain Relevance 0.96
Radioligand binding studies indicated that there was a significant decrease in apparent kappa-opioid receptor density due to antisense oligodeoxynucleotide treatment.
Negative_regulation (decrease) of kappa-opioid receptor associated with kappa opioid receptor
5) Confidence 0.58 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10448926 Disease Relevance 0.24 Pain Relevance 0.30
The findings of the present study demonstrated that chronic blockade of the kappa receptor results in augmentation of kappa agonist-induced stimulation of the HPA axis activity (functional supersensitivity).
Negative_regulation (blockade) of kappa receptor associated with agonist
6) Confidence 0.57 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8396634 Disease Relevance 0.15 Pain Relevance 0.35
Visualization of mu opiate receptor downregulation following morphine treatment in neonatal rat brain.
Negative_regulation (downregulation) of mu opiate receptor in brain associated with opioid receptor 1 and morphine
7) Confidence 0.57 Published 1991 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 1664787 Disease Relevance 0 Pain Relevance 0.83
Such antagonism of adrenergic tone during circulatory shock may help to explain some of the benefit of opiate receptor blockade in this condition.
Negative_regulation (blockade) of opiate receptor associated with shock and opiate
8) Confidence 0.55 Published 1985 Journal Circ. Shock Section Abstract Doc Link 3000640 Disease Relevance 0.41 Pain Relevance 0.59
Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity.
Negative_regulation (diminished) of opiate receptor associated with opiate, potency and morphine
9) Confidence 0.55 Published 1979 Journal Brain Res. Section Title Doc Link 226219 Disease Relevance 0.08 Pain Relevance 1.11
Therefore, in the face of continued exposure to an opioid agonist, periodic reduction in opiate receptor occupancy should reduce tolerance.
Negative_regulation (reduction) of opiate receptor in face associated with mu agonist, tolerance and opiate
10) Confidence 0.54 Published 1997 Journal Pain Section Abstract Doc Link 9150285 Disease Relevance 0 Pain Relevance 1.10
Morphiceptin: biphasic inhibition of mu-opiate receptor ligands.
Negative_regulation (inhibition) of mu-opiate receptor associated with analgesic and opiate
11) Confidence 0.53 Published 1984 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 6096895 Disease Relevance 0 Pain Relevance 0.57
However, prolonged exposure to nitrous oxide (18 h) decreased the brainstem opiate receptor density approximately 20 per cent, without a change in apparent receptor affinity.
Negative_regulation (decreased) of brainstem opiate receptor in brainstem associated with medulla and opiate
12) Confidence 0.51 Published 1982 Journal Anesthesiology Section Abstract Doc Link 6283950 Disease Relevance 0 Pain Relevance 0.89
Oprl1 receptor transcript levels, as determined by Northern blot analysis, were reduced by approximately 50% in oprl1(-/-) rats compared to wild-type controls (oprl1(+/+)), and no alternative spliced transcripts were observed.
Negative_regulation (reduced) of Oprl1 receptor
13) Confidence 0.43 Published 2009 Journal Neuroscience Section Abstract Doc Link 19527777 Disease Relevance 0.40 Pain Relevance 0.67
It appears that chronic morphine treatment decreases the affinity of the opiate receptor for morphine.
Negative_regulation (decreases) of opiate receptor associated with opiate and morphine
14) Confidence 0.43 Published 1975 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1197922 Disease Relevance 0 Pain Relevance 1.77
To understand opioid peptide involvement in mediation of the changes obtained, this analysis was also done during opiate receptor blockade by naloxone.
Negative_regulation (blockade) of opiate receptor associated with narcan, opiate and opioid
15) Confidence 0.43 Published 1989 Journal Int. J. Neurosci. Section Abstract Doc Link 2485833 Disease Relevance 0.34 Pain Relevance 0.47
These results show that developmental events are dictated by the duration of opiate receptor blockade and provide compelling evidence that endogenous opioid systems play a crucial role in growth.
Negative_regulation (blockade) of opiate receptor associated with endogenous opioid and opiate
16) Confidence 0.43 Published 1984 Journal Life Sci. Section Abstract Doc Link 6092812 Disease Relevance 0 Pain Relevance 0.62
The drug was used to observe effects of opiate receptor blockade on cells of the pituitary gland and adjacent hypothalamus.
Negative_regulation (blockade) of opiate receptor in pituitary gland associated with opiate
17) Confidence 0.43 Published 1984 Journal Neurochem. Res. Section Abstract Doc Link 6738790 Disease Relevance 0 Pain Relevance 0.27
We suggest that kappa-receptor down-regulation occurs as a result of elevated release of opioid peptides induced by chronic osmotic stimulation.
Negative_regulation (down-regulation) of kappa-receptor associated with opioid
18) Confidence 0.43 Published 1988 Journal Brain Res. Section Abstract Doc Link 2896058 Disease Relevance 0 Pain Relevance 0.26
Prolonged exposure to nitrous oxide decreased opiate receptor density in rat brainstem.
Negative_regulation (decreased) of opiate receptor in brainstem associated with medulla and opiate
19) Confidence 0.43 Published 1982 Journal Anesthesiology Section Title Doc Link 6283950 Disease Relevance 0 Pain Relevance 0.86
The taste strongly promoted drinking, and the consequent fluid consumption proved to be very sensitive to opiate receptor blockade.
Negative_regulation (blockade) of opiate receptor associated with opiate
20) Confidence 0.43 Published 1982 Journal Subst Alcohol Actions Misuse Section Abstract Doc Link 7167863 Disease Relevance 0.13 Pain Relevance 0.29

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