INT133508

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.37
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TKTL1) cytoplasm (TKTL1)
Anatomy Link Frequency
hip 2
knee 2
spinal 1
TKTL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 407 99.92 Very High Very High Very High
Perioperative pain 12 99.60 Very High Very High Very High
anesthesia 28 99.44 Very High Very High Very High
Pain 100 97.96 Very High Very High Very High
nerve block 140 92.96 High High
Opioid 8 90.04 High High
analgesia 86 87.92 High High
Analgesic 16 86.44 High High
local anesthetic 30 70.80 Quite High
Morphine 32 69.20 Quite High
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 181 99.92 Very High Very High Very High
Post Operative Pain 12 99.60 Very High Very High Very High
Pain 118 97.96 Very High Very High Very High
Disease Progression 1 97.48 Very High Very High Very High
Fatigue 1 95.96 Very High Very High Very High
Osteoarthritis 230 94.76 High High
Rupture 48 86.04 High High
Disease 33 83.72 Quite High
Injury 124 82.56 Quite High
Infection 2 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, having a sibling who had undergone TKR did not significantly increase the risk for hip arthroplasty (P > 0.4).
Positive_regulation (undergone) of TKR in hip
1) Confidence 0.60 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526562 Disease Relevance 0.05 Pain Relevance 0.03
Increased risk for TKR among siblings of TKR probands observed by crude odds testing might be explained by prior personal experience of successful hip arthroplasty, female sex, or old age.
Positive_regulation (Increased) of TKR in hip
2) Confidence 0.44 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526562 Disease Relevance 0.07 Pain Relevance 0
Results suggest that the decision to undergo TKR is not related to symptoms alone, but to personal meanings.
Positive_regulation (undergo) of TKR
3) Confidence 0.40 Published 2006 Journal Soc Sci Med Section Abstract Doc Link 16473445 Disease Relevance 0.51 Pain Relevance 0.16
As prevalence of OA is increasing, TKR is expected to play an important role in reducing pain and improving physical functioning and HRQoL of patients[21].
Positive_regulation (increasing) of TKR associated with pain and osteoarthritis
4) Confidence 0.21 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2933708 Disease Relevance 0.73 Pain Relevance 0.35
This was a two-year non-randomized prospective observational study in knee osteoarthritis (OA) patients undergone TKR.
Positive_regulation (undergone) of TKR in knee associated with knee osteoarthritis and osteoarthritis
5) Confidence 0.18 Published 2010 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC2933708 Disease Relevance 0.34 Pain Relevance 0.17
After gaining approval of the Institutional Ethics Committee and written informed consent, 88 ASA physical status I or II female patients scheduled to undergo elective unilateral TKR under spinal anesthesia (SA) were enrolled in this study.
Positive_regulation (undergo) of TKR in spinal associated with anesthesia
6) Confidence 0.13 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881523 Disease Relevance 0.42 Pain Relevance 1.74
Therefore, further study is needed to evaluate the effect of epinephrine added to bupivacaine during femoral infusion to provide postoperative pain relief in patients undergoing TKR.
Positive_regulation (undergoing) of TKR associated with perioperative pain
7) Confidence 0.13 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2881523 Disease Relevance 0.41 Pain Relevance 0.92
A total of 95 patients undergoing elective TKR for OA were recruited.
Positive_regulation (undergoing) of TKR associated with osteoarthritis
8) Confidence 0.02 Published 2010 Journal J Orthop Traumatol Section Abstract Doc Link PMC2948128 Disease Relevance 0.88 Pain Relevance 0.35
This is the first study, to the best of our knowledge, which has attempted to assess the integrity of the ACL in patients undergoing TKR by means of detailed questionnaire and examination (including KT-1000 assessment), and then correlating these findings with the intra-operative findings at the time of TKR.
Positive_regulation (undergoing) of TKR
9) Confidence 0.02 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2948128 Disease Relevance 0.28 Pain Relevance 0.08
ACL deficiency is uncommon in patients undergoing TKR for OA, and does not worsen pre-operative function.



Positive_regulation (undergoing) of TKR associated with osteoarthritis
10) Confidence 0.02 Published 2010 Journal J Orthop Traumatol Section Abstract Doc Link PMC2948128 Disease Relevance 0.91 Pain Relevance 0.39
An observational study was undertaken in patients undergoing TKR for end-stage OA, to assess clinical findings with function (general, knee OA-specific and ACL-specific), and to relate that to the macroscopic appearance of the ACL at surgery.


Positive_regulation (undergoing) of TKR in knee associated with osteoarthritis
11) Confidence 0.02 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2948128 Disease Relevance 1.77 Pain Relevance 0.60

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