INT13352

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 11
Total Number 15
Disease Relevance 3.91
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kitl) extracellular region (Kitl) cell adhesion (Kitl)
plasma membrane (Kitl) cytoskeleton (Kitl) cytoplasm (Kitl)
Anatomy Link Frequency
brain 3
blood 1
lymph nodes 1
plasma 1
DC101 1
Kitl (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 38 100.00 Very High Very High Very High
Central grey 16 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
deep brain stimulation 3 100.00 Very High Very High Very High
analgesia 14 99.96 Very High Very High Very High
electroacupuncture 13 99.60 Very High Very High Very High
mu opioid receptor 1 99.12 Very High Very High Very High
tolerance 3 98.60 Very High Very High Very High
Analgesic 4 98.56 Very High Very High Very High
aspirin 26 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 23 100.00 Very High Very High Very High
Stress 13 99.82 Very High Very High Very High
Shock 4 99.50 Very High Very High Very High
Intractable Pain 1 98.08 Very High Very High Very High
Pain 2 97.64 Very High Very High Very High
Cold Sores 4 93.68 High High
Hepatitis 1 89.04 High High
Immunodeficiency 1 88.52 High High
Cancer 170 83.60 Quite High
Morphine Dependence 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the amines tested affect the fluidity of Con A receptors by impairment of cell membrane structural proteins and result in the increase of the susceptibility of cells to agglutination by Con A.
Regulation (affect) of Con
1) Confidence 0.45 Published 1982 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 6808705 Disease Relevance 0 Pain Relevance 0.15
In order to study the contribution of the electronic, hydrophobic, and conformational properties of the amino acid residue at position 3 in deltorphin C on binding to delta and mu opioid receptors, a series of 5- and 6-membered ring and bicyclic amino acid replacements at position 3 were prepared by solution synthesis methods.
Regulation (contribution) of C on associated with mu opioid receptor
2) Confidence 0.44 Published 1993 Journal J. Med. Chem. Section Abstract Doc Link 8254604 Disease Relevance 0 Pain Relevance 0.09
Met-enkephalin (ME) in the range of concentrations 10(-15) M to 10(-9) M has exhibited an immunomodulating effect on concanavalin A (Con A) induced proliferation of mice lymphocytes from lymph nodes in vitro.
Regulation (effect) of Con in lymph nodes associated with enkephalin
3) Confidence 0.36 Published 1994 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 7798596 Disease Relevance 0 Pain Relevance 0.57
In addition, DC101 treatment significantly affected this process in Con- and Rac1-siRNA transfected aortic rings from both genotypes (P<0.01, Figure 6D).


Regulation (affected) of Con in DC101
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Our results using Western blot analysis showed that the mPER1 immunoreactivity exhibited a strong circadian rhythm in the brains of the control (Con), morphine-dependent (MD), and morphine-withdrawal (MW) mice.
Regulation (control) of Con in brains associated with withdrawal and morphine
5) Confidence 0.24 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.22 Pain Relevance 0.75
On the other hand, FS- and PSY-stress did not affect CLO analgesia and failed to block the tolerance development.
Neg (not) Regulation (affect) of CLO associated with stress, shock, tolerance, analgesia and clonidine
6) Confidence 0.20 Published 1991 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 1667019 Disease Relevance 0.79 Pain Relevance 1.58
As a negative control pSico-Con, targeting firefly luciferase was also used.
Regulation (targeting) of Con
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.42 Pain Relevance 0
[Evaluation of estimated blood concentration of propofol on wake-up using "ConGrase", a software to control the syringe pump for propofol infusion].
Regulation (control) of ConGrase in blood
8) Confidence 0.07 Published 1998 Journal Masui Section Title Doc Link 9834602 Disease Relevance 0 Pain Relevance 0.05
Also in the present study, sequence analysis of EHV-1 viral DNA isolated from lungs of siRNA–treated infected mice did not show any mutations in the targeted gB and Ori genes (data not shown), indicating that escape mutation might not be as concerning for DNA viruses.
Regulation (targeted) of gB in lungs
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.45 Pain Relevance 0.09
The effects of concanavalin A (Con A) on plasma and brain concentration of aspirin (Asp) were investigated in rats.
Spec (investigated) Regulation (effects) of Con in brain associated with aspirin
10) Confidence 0.03 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3794991 Disease Relevance 0 Pain Relevance 0.36
The effects of concanavalin A (Con A) on plasma and brain concentration of aspirin (Asp) were investigated in rats.
Spec (investigated) Regulation (effects) of Con in plasma associated with aspirin
11) Confidence 0.01 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3794991 Disease Relevance 0 Pain Relevance 0.36
In the current study we assessed the participation of the periaqueductal gray (PAG) in electroacupuncture's (EA) analgesic effects applied to the Zusanli point (36S) under carefully controlled stress conditions.
Regulation (participation) of periaqueductal gray associated with stress, analgesic, electroacupuncture and central grey
12) Confidence 0.00 Published 2003 Journal Brain Res. Section Abstract Doc Link 12738063 Disease Relevance 0.74 Pain Relevance 0.85
OBJECT: The periventricular gray (PVG) zone and its continuation, the periaqueductal gray (PAG) substance, have been targets for deep brain stimulation (DBS) in the alleviation of intractable pain for longer than two decades.
Regulation (targets) of periaqueductal gray in brain associated with deep brain stimulation, intractable pain, urological neuroanatomy and central grey
13) Confidence 0.00 Published 2005 Journal J. Neurosurg. Section Abstract Doc Link 16381189 Disease Relevance 0.37 Pain Relevance 0.33
The effect of morphine infused into 4 hypothalamic locations and the periaqueductal gray (PAG) on cold-stimulated thyrotropin (TSH) secretion was studied in male rats.
Regulation (effect) of periaqueductal gray associated with central grey and morphine
14) Confidence 0.00 Published 1984 Journal Life Sci. Section Abstract Doc Link 6482649 Disease Relevance 0.28 Pain Relevance 0.49
The aim of this paper is to investigate the corticofugal modulation of nucleus periaqueductal gray (PAG) after electroacupuncture by topical administration of GABA on frontal cortex.
Spec (investigate) Regulation (modulation) of periaqueductal gray in frontal cortex associated with gaba, urological neuroanatomy, electroacupuncture and central grey
15) Confidence 0.00 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2125890 Disease Relevance 0.64 Pain Relevance 0.41

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