INT133525

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sptbn1) plasma membrane (Sptbn1) nucleus (Sptbn1)
protein complex (Sptbn1) cytoplasm (Sptbn1)
Anatomy Link Frequency
cerebrum 1
cerebral cortex 1
vesicle 1
Sptbn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 99.36 Very High Very High Very High
induced neuropathy 2 96.72 Very High Very High Very High
cytokine 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 2 97.96 Very High Very High Very High
Neuropathic Pain 2 96.40 Very High Very High Very High
Drug Induced Neurotoxicity 2 94.08 High High
Stress 9 76.84 Quite High
Shock 7 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggested that the changes of cytoskeleton protein contents in rat cerebrum were associated with the intoxication of carbon disulfide, which might be involved in the development of carbon disulfide neurotoxicity.
Regulation (changes) of cytoskeleton protein in cerebrum associated with drug induced neurotoxicity and poisoning
1) Confidence 0.10 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16474999 Disease Relevance 0.19 Pain Relevance 0.04
Carbon disulfide-induced changes in cytoskeleton protein content of rat cerebral cortex.
Regulation (changes) of cytoskeleton protein in cerebral cortex associated with cerebral cortex
2) Confidence 0.10 Published 2006 Journal Neurochem. Res. Section Title Doc Link 16474999 Disease Relevance 0.10 Pain Relevance 0.15
The phenotype of the calorie-independent IF-specific genes in the males contained the following GO term motifs: steroidal function (cholesterol metabolism); intracellular vesicle dynamics (intracellular transport, microtubule cytoskeleton organization, regulation of endocytosis); regulation of protein catabolism/degradation (proteolysis during cellular protein catabolism, ubiquitin-dependent protein catabolism, protein ubiquitination, ubiquitin cycle, small conjugating protein-specific protease activity, cysteine-type endopeptidase activity); cell signaling activity (signal transduction, amino acid phosphorylation, ATP binding, Ser/Thr kinase activity, Tyr kinase activity); transcriptional/translational regulation (RNA polymerase II activity, nuclear mRNA splicing, transcriptional coactivator activity, regulation of translation); stress management (response to stress).
Neg (independent) Regulation (regulation) of microtubule cytoskeleton organization in vesicle associated with stress
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.15 Pain Relevance 0

General Comments

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