INT13353

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 7
Speculated 4
Reported most in Abstract
Documents 332
Total Number 335
Disease Relevance 248.75
Pain Relevance 148.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
plasma 19
spinal cord 12
macrophages 11
nerve 9
dorsal root ganglia 9
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1283 100.00 Very High Very High Very High
cytokine 1262 100.00 Very High Very High Very High
fibrosis 324 100.00 Very High Very High Very High
Pain 306 100.00 Very High Very High Very High
Inflammatory mediators 175 100.00 Very High Very High Very High
COX2 161 100.00 Very High Very High Very High
Spinal cord 142 100.00 Very High Very High Very High
aspirin 132 100.00 Very High Very High Very High
Arthritis 96 100.00 Very High Very High Very High
dorsal root ganglion 79 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1665 100.00 Very High Very High Very High
Cancer 418 100.00 Very High Very High Very High
Necrosis 380 100.00 Very High Very High Very High
Adhesions 191 100.00 Very High Very High Very High
Arthritis 130 100.00 Very High Very High Very High
Apoptosis 128 100.00 Very High Very High Very High
Pressure And Volume Under Development 122 100.00 Very High Very High Very High
Ganglion Cysts 81 100.00 Very High Very High Very High
Urological Neuroanatomy 50 100.00 Very High Very High Very High
Cystic Fibrosis 31 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, accumulation of mRNA specific for TNFalpha is significantly increased in neurons within a region of the brain containing the locus coeruleus at days 2, 8, and 14 postligature placement, contemporaneous with the development of hyperalgesia.
Positive_regulation (accumulation) of TNFalpha in locus coeruleus
1) Confidence 0.70 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0 Pain Relevance 0
Additionally, TNFalpha activity is increased in the thoracolumbar region of the spinal cord by day 4 postligature placement and remains elevated during hyperalgesia (day 8), as well as after hyperalgesia has dissipated (day 14).
Positive_regulation (elevated) of TNFalpha in spinal cord
2) Confidence 0.70 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0.05 Pain Relevance 0
Additionally, TNFalpha activity is increased in the thoracolumbar region of the spinal cord by day 4 postligature placement and remains elevated during hyperalgesia (day 8), as well as after hyperalgesia has dissipated (day 14).
Positive_regulation (increased) of TNFalpha in spinal cord
3) Confidence 0.70 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0.05 Pain Relevance 0
Inhibitory effect of amygdalin on lipopolysaccharide-inducible TNF-alpha and IL-1beta mRNA expression and carrageenan-induced rat arthritis.
Positive_regulation (inducible) of TNF-alpha associated with arthritis
4) Confidence 0.70 Published 2008 Journal J. Microbiol. Biotechnol. Section Title Doc Link 18955812 Disease Relevance 0.76 Pain Relevance 0.48
Although paracetamol significantly increased exudate TNF-alpha level compared to the control group and NCX 701 group, neither paracetamol, nor NCX701 treatments changed the levels of exudate IL-1beta significantly.
Positive_regulation (increased) of TNF-alpha associated with paracetamol
5) Confidence 0.70 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320862 Disease Relevance 0.27 Pain Relevance 1.08
Aspirin, at 10, 30 and 100 mg/kg doses, increased IL-1beta levels in exudates, however, only the highest dose lead to a significant increase when compared to control, whereas a significant increase in TNF-alpha level was observed at all doses tested.
Positive_regulation (increase) of TNF-alpha associated with aspirin
6) Confidence 0.70 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320862 Disease Relevance 0.33 Pain Relevance 0.75
Unlike paracetamol, which increased exudate TNF-alpha level, NCX 701 had no effect on TNF-alpha level in the exudates.
Positive_regulation (increased) of TNF-alpha associated with paracetamol
7) Confidence 0.70 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320862 Disease Relevance 0.07 Pain Relevance 0.90
Recently, increased plasma levels of tumor necrosis factor-alpha (TNF-alpha), which can increase leukocyte adherence, have been reported after administration of indomethacin.
Positive_regulation (increased) of tumor necrosis factor-alpha in plasma associated with necrosis and cancer
8) Confidence 0.70 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772499 Disease Relevance 0.59 Pain Relevance 0.39
Administration of indomethacin to rats resulted in a significant elevation of plasma TNF-alpha levels within 30 min and the development of gastric erosions.
Positive_regulation (elevation) of TNF-alpha in plasma
9) Confidence 0.70 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772499 Disease Relevance 0.59 Pain Relevance 0.39
Recently, increased plasma levels of tumor necrosis factor-alpha (TNF-alpha), which can increase leukocyte adherence, have been reported after administration of indomethacin.
Positive_regulation (increased) of TNF-alpha in plasma associated with necrosis and cancer
10) Confidence 0.70 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772499 Disease Relevance 0.59 Pain Relevance 0.39
Induction of tumor necrosis factor-alpha and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine.
Positive_regulation (Induction) of tumor necrosis factor-alpha associated with necrosis, cancer, injury and apoptosis
11) Confidence 0.70 Published 1997 Journal Scand. J. Gastroenterol. Section Title Doc Link 9246701 Disease Relevance 0.75 Pain Relevance 0.19
Since recent studies have shown that the gut is an important source of norepinephrine (NE) release during early sepsis and enterectomy prior to the onset of sepsis attenuates TNF-alpha production, we hypothesized that gut-derived NE plays a major role in upregulating TNF-alpha via the activation of alpha(2)-adrenoceptors on Kupffer cells.
Positive_regulation (upregulating) of TNF-alpha in gut associated with sepsis
12) Confidence 0.70 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.45 Pain Relevance 0.19
Although previous studies have demonstrated that plasma levels of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) increase during early sepsis, the precise mechanism responsible for its upregulation remains to be elucidated.
Positive_regulation (increase) of TNF-alpha in plasma associated with necrosis, cancer, sepsis and cytokine
13) Confidence 0.70 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.46 Pain Relevance 0.07
Furthermore, the increased cellular levels of TNF-alpha in Kupffer cells after in vivo administration of NE was also blocked by yohimbine.
Positive_regulation (increased) of TNF-alpha in Kupffer cells
14) Confidence 0.70 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.17 Pain Relevance 0.26
Axotomy-induced up-regulation of tumor necrosis factor-alpha in the dorsal root ganglia.
Positive_regulation (regulation) of tumor necrosis factor-alpha in dorsal root ganglia associated with necrosis and cancer
15) Confidence 0.70 Published 2008 Journal Neurol. Res. Section Title Doc Link 18489817 Disease Relevance 0.94 Pain Relevance 0.53
Hemorrhage also increases the circulating levels of cytokines such as TNF-alpha.
Positive_regulation (increases) of TNF-alpha associated with cva and cytokine
16) Confidence 0.70 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8587433 Disease Relevance 0.64 Pain Relevance 0.15
TNF alpha was not elevated after mild injury.
Neg (not) Positive_regulation (elevated) of TNF alpha associated with injury
17) Confidence 0.70 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10229121 Disease Relevance 1.26 Pain Relevance 0.22
TNF alpha levels increased significantly in the injured cortex at 1 and 4, but not at 12, 24 or 72 h after severe lateral fluid-percussion trauma (2.6-2.7 atm).
Neg (not) Positive_regulation (increased) of TNF alpha in lateral associated with injury
18) Confidence 0.70 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10229121 Disease Relevance 1.25 Pain Relevance 0.15
At 1 and 4 h after severe TBI, marked increases of TNF alpha were localized immunocytochemically to neurons of the injured cerebral cortex.
Positive_regulation (increases) of TNF alpha in cerebral cortex associated with cerebral cortex and brain injury
19) Confidence 0.70 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10229121 Disease Relevance 1.30 Pain Relevance 0.23
In pathophysiological conditions, increased blood-borne TNF-alpha induces a broad range of biological effects, including activation of the hypothalamic-pituitary-adrenal axis and sympathetic drive.
Positive_regulation (increased) of TNF-alpha in pituitary
20) Confidence 0.69 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12626358 Disease Relevance 0 Pain Relevance 0.07

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