INT133538

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rhoq) intracellular (Rhoq) GTPase activity (Rhoq)
cytoplasm (Rhoq)
Rhoq (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 2 50.00 Quite Low
antagonist 1 38.24 Quite Low
Inflammation 22 26.64 Quite Low
neuralgia 1 10.00 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 74.72 Quite High
Nervous System Injury 2 50.00 Quite Low
Overactive Bladder 18 46.92 Quite Low
Apoptosis 4 39.04 Quite Low
INFLAMMATION 26 26.64 Quite Low
Dermatological Disease 1 25.52 Quite Low
Disease 3 25.12 Quite Low
Bladder Cancer 9 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although clinical outcome is often poor at present, recent preclinical research provides several promising approaches and new target molecules for therapeutic intervention, such as neurotrophic factor (GDNF and ARTN) treatment of neuropathic pain, manipulation of the small Rho GTPases (Rac, Rho, Cdc42, Tc10), lipid raft manipulation, gene silencing with DNA enzyme and siRNA.
Gene_expression (manipulation) of Tc10
1) Confidence 0.05 Published 2005 Journal Restor. Neurol. Neurosci. Section Body Doc Link 16477099 Disease Relevance 0 Pain Relevance 0
A small GTPase, interferon-inducible, guanylate binding protein 2 (GBP2) was found in this pathway downstream of IL-4 [21].
Gene_expression (found) of small GTPase
2) Confidence 0.03 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.07 Pain Relevance 0

General Comments

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