INT13354

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Context Info
Confidence 0.72
First Reported 1991
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 108
Total Number 110
Disease Relevance 85.81
Pain Relevance 42.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
blood 7
plasma 2
skin 2
sciatic nerve 2
sacroiliac joints 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1353 100.00 Very High Very High Very High
cytokine 1187 100.00 Very High Very High Very High
methotrexate 280 100.00 Very High Very High Very High
Etanercept 224 100.00 Very High Very High Very High
antagonist 98 100.00 Very High Very High Very High
chemokine 94 100.00 Very High Very High Very High
Inflammatory response 91 100.00 Very High Very High Very High
Leflunomide 37 100.00 Very High Very High Very High
Adalimumab 243 99.92 Very High Very High Very High
headache 19 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1532 100.00 Very High Very High Very High
Cancer 354 100.00 Very High Very High Very High
Stress 197 100.00 Very High Very High Very High
Necrosis 189 100.00 Very High Very High Very High
Adhesions 64 100.00 Very High Very High Very High
Headache 19 99.88 Very High Very High Very High
Targeted Disruption 166 99.86 Very High Very High Very High
Neuropathic Pain 32 99.86 Very High Very High Very High
Disease 805 99.78 Very High Very High Very High
Low Back Pain 365 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, morphine inhibited expression of TNF-alpha mRNA in BALB/3T3 cells (IC50, 1.6 mM), but not expression of early response genes.
Transcription (expression) of TNF-alpha associated with morphine
1) Confidence 0.72 Published 1996 Journal Carcinogenesis Section Abstract Doc Link 8968046 Disease Relevance 1.12 Pain Relevance 0.82
Indomethacin or lysine-acetylsalicylic acid concentration-dependently inhibited prostaglandin E(2) biosynthesis and, at concentrations causing near-complete inhibition, enhanced TNFalpha mRNA and protein expression without significantly influencing cyclooxygenase-2 mRNA.
Transcription (expression) of TNFalpha associated with aspirin
2) Confidence 0.72 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.15 Pain Relevance 0.28
When IL-6 binds to its receptor, a mechanism is triggered blocking Janus Kinase signal and activator of transcription (JAK/STAT) mediated transcription of IL-1 and TNF-?
Transcription (transcription) of TNF
3) Confidence 0.69 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 0.57 Pain Relevance 0.35
In return, IL-6 inhibits the transcription of TNF-?
Transcription (transcription) of TNF
4) Confidence 0.69 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 0.98 Pain Relevance 0.46
Moreover, we found that AM404 specifically inhibited both IL-2 and TNF-alpha gene transcription and TNF-alpha synthesis in CD3/CD28-stimulated Jurkat T cells in a FAAH independent way.
Transcription (transcription) of TNF-alpha in T cells
5) Confidence 0.69 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17196940 Disease Relevance 0 Pain Relevance 0.21
The mRNA levels of the pro-inflammatory cytokines, TNF-?
Transcription (levels) of TNF associated with inflammation and cytokine
6) Confidence 0.69 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.89 Pain Relevance 0.29
Elevated TNF-alpha levels in the culture medium were reliably detected at 360 minutes after exposure to LPS.
Transcription (detected) of TNF-alpha
7) Confidence 0.69 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.42 Pain Relevance 0.16
For instance, KGF upregulates the transcription factor Nrf 2 that encodes genes playing a role in detoxifying radical oxygen species (Braun et al 2002; auf dem Keller et al 2004), attenuating TNF-?
Transcription (transcription) of TNF
8) Confidence 0.67 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.58 Pain Relevance 0.11
We previously reported that in a rat model of mixed reflux esophagitis, intraduodenal rebamipide significantly inhibited the increased expression of mRNA and protein for CINC-1 and TNF-?
Transcription (expression) of TNF associated with acid reflux
9) Confidence 0.67 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.87 Pain Relevance 0.44
These features may also explain some variability among studies on the abundance of TNF-?
Transcription (abundance) of TNF
10) Confidence 0.67 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.91 Pain Relevance 0.39
gene, then translocates from the cytoplasm to the nucleus where it activates transcription of target genes such as TNF?
Transcription (transcription) of TNF in nucleus
11) Confidence 0.67 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0 Pain Relevance 0.13
receptor knockout mice using an OVA model, and our study also demonstrated that TNF-?
Transcription (demonstrated) of TNF associated with targeted disruption
12) Confidence 0.67 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.44 Pain Relevance 0.30
It has been demonstrated that thalidomide selectively inhibits the TNF-alpha and IL-6 mRNA expression in human peripheral blood mononuclear cells [10].
Transcription (expression) of TNF-alpha in blood
13) Confidence 0.63 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2831027 Disease Relevance 1.24 Pain Relevance 0.30
Indeed, these transcripts covered such diverse proteins and functions as: ribosomal components (LAMR1, MRPL22, RPL35, RPS16, RPS28), which may suggest the existence of a TNF?
Transcription (existence) of TNF
14) Confidence 0.63 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.17 Pain Relevance 0
Further our results indicated that shikonin suppressed the basal transcription and activator-regulated transcription of TNF-alpha by inhibiting the binding of transcription factor IID protein complex (TATA box-binding protein) to TATA box.
Transcription (transcription) of TNF-alpha
15) Confidence 0.62 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.34 Pain Relevance 0.12
B and activation of the transcription of various proinflammatory cytokines [13] (IL1A, IL1B, TNFA, IL6, IL8,...etc).
Transcription (transcription) of TNFA associated with cytokine
16) Confidence 0.61 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.41 Pain Relevance 0.25
We demonstrate here that TNF?
Transcription (demonstrate) of TNF
17) Confidence 0.61 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.23 Pain Relevance 0.16
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Transcription (transcription) of TNF-alpha associated with melanocortin 1 receptor
18) Confidence 0.57 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.34 Pain Relevance 0.87
Indeed, results showed that ex-vivo cultures of inflamed colonic biopsies re-stimulated with these peptides were able to consistently induce a proinflammatory cytokine profile dominated by increased mRNA levels of TNF?
Transcription (levels) of TNF associated with cytokine
19) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.69 Pain Relevance 0.30
The opposite variations in transcript levels seen in responders compared to non-responders at three months strongly suggest that the informative transcripts retained in our study originated from TNF?
Transcription (originated) of TNF
20) Confidence 0.55 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.23 Pain Relevance 0.08

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