INT133549

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 42
Total Number 45
Disease Relevance 27.84
Pain Relevance 14.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il15) extracellular region (Il15) cytoplasm (Il15)
Anatomy Link Frequency
endothelial cells 4
macrophages 3
fibroblast 2
NK cells 2
mononuclear cells 2
Il15 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 989 100.00 Very High Very High Very High
cytokine 853 100.00 Very High Very High Very High
Inflammation 673 100.00 Very High Very High Very High
Infliximab 438 99.92 Very High Very High Very High
Eae 6 99.72 Very High Very High Very High
Inflammatory response 57 99.34 Very High Very High Very High
Arthritis 314 99.16 Very High Very High Very High
Sciatic nerve 2 98.08 Very High Very High Very High
Neuropathic pain 1 96.40 Very High Very High Very High
abatacept 35 81.08 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 989 100.00 Very High Very High Very High
INFLAMMATION 752 100.00 Very High Very High Very High
Arthritis 331 99.16 Very High Very High Very High
Disease 445 98.92 Very High Very High Very High
Injury 172 98.88 Very High Very High Very High
Atherosclerotic Plaque 16 98.48 Very High Very High Very High
Coronary Artery Disease 21 98.40 Very High Very High Very High
Cancer 269 97.68 Very High Very High Very High
Necrosis 127 97.40 Very High Very High Very High
Atherosclerosis 95 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of primary murine microglial cultures with GD3 abolished IL-15 production, without affecting cellular viability, but decreased the production of nitric oxide, a direct sensor of inflammation and nuclear factor-kappaB activity.
Gene_expression (production) of IL-15 associated with inflammation
1) Confidence 0.69 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16477650 Disease Relevance 0.38 Pain Relevance 0.22
SE, AU and ME developed the immunohistochemical stainings for the expression of IL-15, performed the stainings for cytokines and the semi-quantitative analysis and computerized image analysis of IL-15, TNF and IFN-?.
Gene_expression (expression) of IL-15 associated with cytokine
2) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.47 Pain Relevance 0.38
IL-15 production by mononuclear cells, which had been primed to produce IL-15, was entirely blocked by both IL-15 neutralizing and IL-15 non-neutralizing antibodies detecting IL-15, thereby demonstrating the specificity of the staining.
Gene_expression (production) of IL-15 in mononuclear cells
3) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.13 Pain Relevance 0.28
Double immunofluorescence staining, performed for two of the patients, revealed co-expression between IL-15, analysed with the neutralizing antibody, and CD163 (macrophages) (Figure 2).
Gene_expression (expression) of IL-15 in macrophages
4) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0 Pain Relevance 0.22
IL-15 production by mononuclear cells, which had been primed to produce IL-15, was entirely blocked by both IL-15 neutralizing and IL-15 non-neutralizing antibodies detecting IL-15, thereby demonstrating the specificity of the staining.
Gene_expression (produce) of IL-15 in mononuclear cells
5) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.13 Pain Relevance 0.28
The inter-individual variability in synovial staining was high for the cytokines IL-15, IL-1?
Gene_expression (high) of IL-15 associated with cytokine
6) Confidence 0.44 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0 Pain Relevance 0.27
The fact that the overall staining for IL-15 did not change during TNF blockade and that IL-15 was present in the inflamed joints of all patients suggests that targeting of IL-15 is an interesting potential therapy in RA irrespective of previous or concomitant therapy with TNF blockade.
Gene_expression (targeting) of IL-15 in joints associated with rheumatoid arthritis
7) Confidence 0.44 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.40 Pain Relevance 0.29
High IL-15 expression, detected in peritoneal macrophages of vitamin D-deficient mice, accelerates T1D development in NOD strain.
Gene_expression (expression) of IL-15 in peritoneal macrophages associated with diabetes mellitus and sprains and strains
8) Confidence 0.42 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.03 Pain Relevance 0.08
In the present investigation, we analyzed the temporal gene expression pattern of IL-17A and its main regulators IL-23 and IL-15 after chronic constriction injury (CCI) of the sciatic nerve, a lesion paradigm inducing neuropathic pain, by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in mice.
Spec (analyzed) Gene_expression (expression) of IL-15 in sciatic nerve associated with eae, injury, neuropathic pain and sciatic nerve
9) Confidence 0.41 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.76 Pain Relevance 0.52
In the synovial membrane of patients with RA, there is a substantial expression of IL-15, predominantly expressed in macrophages but also in fibroblast-like synoviocytes and endothelial cells [3-5].
Gene_expression (expressed) of IL-15 in endothelial cells associated with rheumatoid arthritis
10) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 1.18 Pain Relevance 0.60
Synovial expression of IL-15 was not correlated with any CD marker or with the presence of any other cytokine.
Gene_expression (expression) of IL-15 associated with cytokine
11) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526582 Disease Relevance 0.86 Pain Relevance 0.50
IL-15 expression was detected in all synovial biopsies taken at baseline.
Gene_expression (expression) of IL-15
12) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526582 Disease Relevance 0.87 Pain Relevance 0.50
IL-15 was detected at baseline in all synovial biopsies; after treatment with infliximab the change in expression diverged, without any correlation with clinical parameters or the expression of other cytokines.
Gene_expression (detected) of IL-15 associated with infliximab and cytokine
13) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.32 Pain Relevance 0.36
A major finding in the present study was that the expression of IL-15 in the synovial tissue of patients with RA was not affected by treatment with three infusions of infliximab.
Gene_expression (expression) of IL-15 associated with infliximab and rheumatoid arthritis
14) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.32 Pain Relevance 0.32
In this study we therefore investigated the effect of infliximab, a TNF-blocking antibody, on the synovial expression of IL-15 in relation to different cell types and the expression of other cytokines.


Gene_expression (expression) of IL-15 associated with infliximab and cytokine
15) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.63 Pain Relevance 0.43
Further, we found a co-expression of IL-15 and CD163 when analysed with double staining, indicating that IL-15 in the RA synovial membrane is predominantly produced by macrophages.
Gene_expression (produced) of IL-15 in macrophages associated with rheumatoid arthritis
16) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.30 Pain Relevance 0.36
Further, we found a co-expression of IL-15 and CD163 when analysed with double staining, indicating that IL-15 in the RA synovial membrane is predominantly produced by macrophages.
Gene_expression (expression) of IL-15 in macrophages associated with rheumatoid arthritis
17) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.31 Pain Relevance 0.39
and IL-17, which in turn stimulate the further production of IL-15, IL-8 and IL-6 in fibroblast-like synoviocytes [7,8].
Gene_expression (production) of IL-15 in fibroblast
18) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 1.06 Pain Relevance 0.59
In this study we investigated the effect of TNF blockade (infliximab) on the synovial expression of IL-15 in RA in relation to different cell types and expression of other cytokines, to elucidate whether or not IL-15 is a possible target for therapy, independently of TNF blockade.
Gene_expression (expression) of IL-15 associated with infliximab, rheumatoid arthritis and cytokine
19) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526582 Disease Relevance 1.02 Pain Relevance 0.49
Synovial biopsies were analysed with immunohistochemistry for expression of IL-15, TNF, IL-1?
Spec (analysed) Gene_expression (expression) of IL-15
20) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526582 Disease Relevance 0.93 Pain Relevance 0.52

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