INT133550

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.64
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
bone marrow 4
nucleus 4
microglial cell 4
fibroblasts 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 150 99.96 Very High Very High Very High
rheumatoid arthritis 231 99.84 Very High Very High Very High
Osteoarthritis 51 98.44 Very High Very High Very High
Morphine 156 95.08 Very High Very High Very High
Substantia nigra 37 91.12 High High
Inflammation 117 90.72 High High
chemokine 29 82.92 Quite High
methotrexate 48 66.24 Quite High
metalloproteinase 57 64.28 Quite High
ischemia 19 60.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 11 100.00 Very High Very High Very High
Rheumatoid Arthritis 231 99.84 Very High Very High Very High
Osteoarthritis 51 98.44 Very High Very High Very High
Sprains And Strains 18 93.96 High High
INFLAMMATION 135 90.72 High High
Necrosis 20 90.04 High High
Injury 29 88.52 High High
Toxicity 36 81.16 Quite High
Cancer 167 79.80 Quite High
Stress 66 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Tlr4 KO mice, however, the expression of RelA, Tnf, Il6, Ccl2, Ccl5, Cxcl10, Gfap, Icam1, Cybb, and Nos2 was significantly reduced relative to WT.
Negative_regulation (reduced) of Gene_expression (expression) of RelA
1) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.49 Pain Relevance 0.17
Moreover, cytokine release was inhibited despite the retention of the p65 (RelA) subunit in the nucleus.
Negative_regulation (inhibited) of Gene_expression (retention) of p65 in nucleus associated with cytokine
2) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.90
Moreover, cytokine release was inhibited despite the retention of the p65 (RelA) subunit in the nucleus.
Negative_regulation (inhibited) of Gene_expression (retention) of RelA in nucleus associated with cytokine
3) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.07 Pain Relevance 0.90
B p65 expression was evident mainly in cells with the morphology of activated microglia, surrounding the human ?
Spec (evident) Negative_regulation (evident) of Gene_expression (expression) of p65 in microglia
4) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0.22
The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line.
Negative_regulation (reducing) of Gene_expression (expression) of p65 in microglial cell associated with cytokine
5) Confidence 0.23 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16477650 Disease Relevance 0.32 Pain Relevance 0.18
Moreover, in RelA deficient fibroblasts, I?
Negative_regulation (deficient) of Gene_expression (fibroblasts) of RelA in fibroblasts
6) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.80 Pain Relevance 0.49
It is suggested, therefore, that the decreased expression of RelA mRNA in RA bone marrow CD34+ cells might also contribute to abnormal response to TNF-?.
Negative_regulation (decreased) of Gene_expression (expression) of RelA mRNA in bone marrow associated with rheumatoid arthritis
7) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.61 Pain Relevance 0.33
Although the expression of RelA mRNA appeared to be lower in RA bone marrow CD34+ cells than in OA bone marrow CD34+ cells, it did not reach statistical significance (p = 0.192150).
Negative_regulation (lower) of Gene_expression (expression) of RelA mRNA in bone marrow associated with rheumatoid arthritis and osteoarthritis
8) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.74 Pain Relevance 0.46
B-p65 and -p50 expression after exposure in Ppar?
Negative_regulation (exposure) of Gene_expression (expression) of p65
9) Confidence 0.16 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.43 Pain Relevance 0.09
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (levels) of Gene_expression (The) of p65
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (levels) of Gene_expression (expression) of p65
11) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (levels) of Gene_expression (expression) of p65
12) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
The expression levels of p65 and p50, as two subunits of NF-?
Negative_regulation (two) of Gene_expression (expression) of p65
13) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.12 Pain Relevance 0
M decrease in IC50 and si-Keap1 + p65 knock down leads to a 5 ?
Negative_regulation (decrease) of Gene_expression (knock) of p65 associated with targeted disruption
14) Confidence 0.10 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.65 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox