INT133567

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 9.54
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
monocyte 1
endometrium 1
kidney 1
mononuclear cells 1
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 206 100.00 Very High Very High Very High
Inflammation 181 100.00 Very High Very High Very High
spinal inflammation 4 99.24 Very High Very High Very High
Etanercept 1 98.08 Very High Very High Very High
rheumatoid arthritis 190 96.74 Very High Very High Very High
Infliximab 1 95.72 Very High Very High Very High
palliative 1 95.40 Very High Very High Very High
ischemia 5 93.96 High High
abatacept 1 81.04 Quite High
corticosteroid 5 78.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 208 100.00 Very High Very High Very High
Congenital Anomalies 3 100.00 Very High Very High Very High
Asthma 315 99.80 Very High Very High Very High
Occupational Lung Diseases 15 99.64 Very High Very High Very High
Low Back Pain 4 99.24 Very High Very High Very High
Injury 248 99.20 Very High Very High Very High
Acute Coronary Syndrome 10 98.16 Very High Very High Very High
Increased Venous Pressure Under Development 88 97.44 Very High Very High Very High
Rheumatoid Arthritis 190 96.74 Very High Very High Very High
Syndrome 5 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its major function is to regulate the inflammatory activity of IL-18 by acting as its soluble decoy receptor [22,23].
Regulation (regulate) of IL-18 associated with inflammation
1) Confidence 0.50 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.80 Pain Relevance 0.51
RESULT(S): IL-18 system mRNA and protein expression was demonstrated in the eutopic endometrium of both adenomyosis and control women.
Regulation (RESULT) of IL-18 in endometrium
2) Confidence 0.43 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.07 Pain Relevance 0
However its basal level of expression influence the IL-18 related uNK recruitment and local cytotoxicity.
Regulation (influence) of IL-18
3) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.51 Pain Relevance 0.08
Indeed, previous results suggested that basic TWEAK expression influences the IL-18 related uNK recruitment and local cytotoxicity.


Regulation (influences) of IL-18
4) Confidence 0.41 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.33 Pain Relevance 0.03
In the present study, we selected two functional IL18 promoter polymorphisms (IL18 -137 and -607), which were suggested to alter the IL18 promoter activity.
Regulation (alter) of IL18
5) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.60 Pain Relevance 0.15
Effects of ramipril on serum monocyte chemoattractant protein 1, interleukin-18, and interleukin-10 in elderly patients with acute coronary syndrome.
Regulation (Effects) of interleukin-18 in monocyte associated with acute coronary syndrome
6) Confidence 0.26 Published 2010 Journal Heart Vessels Section Title Doc Link 20339966 Disease Relevance 1.02 Pain Relevance 0.12
The aim of the present study was to investigate possible abnormalities in IL-18 and fetuin-A levels in AS.
Spec (possible) Regulation (abnormalities) of IL-18 associated with spinal inflammation and congenital anomalies
7) Confidence 0.20 Published 2010 Journal Int J Rheum Dis Section Abstract Doc Link 20374388 Disease Relevance 0.65 Pain Relevance 0.36
Measurement of PGE2, IL-10 and IL-18 content in culture medium
Regulation (content) of IL-18
8) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0 Pain Relevance 0
The concentrations of IL-12 and IL-18 were determined by ELISA tests.
Regulation (concentrations) of IL-18
9) Confidence 0.12 Published 2006 Journal Exp. Oncol. Section Abstract Doc Link 17285118 Disease Relevance 0.92 Pain Relevance 0.10
IL-18 modulation and asthma
Regulation (modulation) of IL-18 associated with asthma
10) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.27 Pain Relevance 0.15
In addition, peripheral blood mononuclear cells of RA patients show low levels of the IL-18 binding protein (a natural inhibitor of IL-18) and reduced sensitivity to stimulation with IL-12/IL-18, indicating profound dysregulation of the IL-18 system [61].


Regulation (dysregulation) of IL-18 in mononuclear cells associated with rheumatoid arthritis
11) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.25 Pain Relevance 0.44
Other biomarkers under investigation include changes in plasma neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels and urinary changes in NGAL, interleukin-18 (IL-18) and kidney injury molecule-1 (KIM-1) [18].
Regulation (changes) of interleukin-18 in kidney associated with injury
12) Confidence 0.04 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.57 Pain Relevance 0
However, newer products are now available to target other inflammatory cytokines including IL-6, IL-8, IL-12, IL-15, IL-18, IL-23.
Regulation (target) of IL-18 associated with inflammation and cytokine
13) Confidence 0.02 Published 2005 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 16479734 Disease Relevance 0.55 Pain Relevance 0.37

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