INT13359

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Context Info
Confidence 0.33
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.60
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SERPINF1) extracellular space (SERPINF1) aging (SERPINF1)
extracellular region (SERPINF1)
Anatomy Link Frequency
monocyte 2
aorta 1
epithelium 1
endothelium 1
SERPINF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 100.00 Very High Very High Very High
Clonidine 7 97.68 Very High Very High Very High
Central nervous system 1 90.08 High High
tetrodotoxin 1 85.96 High High
sodium channel 3 85.12 High High
Inflammation 49 81.08 Quite High
agonist 9 68.60 Quite High
Dismenorea 5 68.24 Quite High
cytokine 14 59.48 Quite High
bDMF 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wound Healing 9 82.60 Quite High
INFLAMMATION 49 81.08 Quite High
Premature Birth 35 75.20 Quite High
Dysmenorrhea 5 68.24 Quite High
Pre-term Labor 6 64.12 Quite High
Infection 5 50.16 Quite High
Cancer 2 27.04 Quite Low
Adhesions 11 18.68 Low Low
Hypoxia 1 12.60 Low Low
Hemorrhage 37 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Candidate proteins which may be responsible for the monocyte pro-migratory activity of Fraction 27 include tissue inhibitor of metalloproteinase 1 (TIMP-1) and proliferation-inducing protein 35 (PEDF).
Negative_regulation (inhibitor) of PEDF in monocyte associated with metalloproteinase
1) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.08
Candidate proteins which may be responsible for the monocyte pro-migratory activity of Fraction 27 include tissue inhibitor of metalloproteinase 1 (TIMP-1) and proliferation-inducing protein 35 (PEDF).
Negative_regulation (inhibitor) of proliferation-inducing protein 35 in monocyte associated with metalloproteinase
2) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.08
These proteins included tissue inhibitor of metalloproteinase 1 (TIMP-1), vimentin, and pigment epithelium-derived growth factor (PEDF).
Negative_regulation (inhibitor) of PEDF in epithelium associated with metalloproteinase
3) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0.15 Pain Relevance 0.05
PEDF is known to be the most potent inhibitor of angiogenesis in the mammalian ocular compartment [40].
Negative_regulation (inhibitor) of PEDF
4) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.45 Pain Relevance 0.21
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of PEDF
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
An inhibitor of endothelium-derived relaxing factor (EDRF) synthase, N omega-nitro-L-arginine methyl ester (L-NAME) (0.65 mM), enhanced the veratridine-induced contraction in rings with an intact endothelium, which suggests that EDRF was being released during the veratridine-induced contraction.
Negative_regulation (inhibitor) of endothelium-derived relaxing factor in endothelium
6) Confidence 0.01 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1667387 Disease Relevance 0 Pain Relevance 0.20
The inhibitory effects of endothelium-derived relaxing factor (EDRF) on the contractions induced by norepinephrine and clonidine in rat aorta were examined.
Spec (examined) Negative_regulation (effects) of endothelium-derived relaxing factor in aorta associated with clonidine
7) Confidence 0.01 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3879308 Disease Relevance 0 Pain Relevance 0.22

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