INT133604

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.81
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fadd) protein complex (Fadd) cytoplasm (Fadd)
Anatomy Link Frequency
brain 2
corpus striatum 1
Fadd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 4 99.22 Very High Very High Very High
agonist 22 98.92 Very High Very High Very High
cerebral cortex 6 98.64 Very High Very High Very High
Opioid 4 98.46 Very High Very High Very High
antagonist 3 98.32 Very High Very High Very High
opiate 16 98.06 Very High Very High Very High
Morphine 12 97.56 Very High Very High Very High
Delta opioid receptors 3 91.44 High High
Cannabinoid 3 85.40 High High
narcan 4 83.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 3 99.48 Very High Very High Very High
Death 11 92.56 High High
Bordatella Infection 1 25.00 Low Low
Opiate Addiction 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opiate drugs (and specifically the delta-agonists) could promote survival signals in the brain through inhibition of FADD, which in turn is dependent on the activation of the antiapoptotic ERK1/2 signaling pathway.
Negative_regulation (inhibition) of FADD in brain associated with agonist and opiate
1) Confidence 0.57 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.07 Pain Relevance 0.77
Pretreatment of rats with SL 327 (a selective MEK1/2 inhibitor that blocks ERK activation) fully prevented the reduction of FADD content induced by SNC-80 in the cerebral cortex (43%) and corpus striatum (29%), demonstrating the direct involvement of ERK1/2 signaling in the regulation of FADD by the opiate agonist.
Negative_regulation (reduction) of FADD in corpus striatum associated with agonist, opiate and cerebral cortex
2) Confidence 0.50 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.19 Pain Relevance 1.18
Opioid drugs have been proposed to promote anti-apoptotic signals in brain through inhibition of FADD protein [GarcĂ­a-Fuster et al., 2007.
Negative_regulation (inhibition) of FADD in brain associated with apoptosis and opioid
3) Confidence 0.40 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18657552 Disease Relevance 0.34 Pain Relevance 0.37
In morphine- and SNC-80-tolerant rats, antagonist-precipitated (2 h) or spontaneous withdrawal (24-48 h) induced a new and sustained inhibition of FADD (13-50%).
Negative_regulation (inhibition) of FADD associated with antagonist, withdrawal and morphine
4) Confidence 0.37 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.21 Pain Relevance 1.18

General Comments

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