INT133605

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fadd) protein complex (Fadd) cytoplasm (Fadd)
Anatomy Link Frequency
brain 2
Fadd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 2 99.78 Very High Very High Very High
agonist 12 98.92 Very High Very High Very High
antagonist 2 98.88 Very High Very High Very High
Morphine 6 98.12 Very High Very High Very High
opiate 10 98.06 Very High Very High Very High
Delta opioid receptors 2 91.44 High High
Cannabinoid 2 86.52 High High
narcan 2 84.32 Quite High
cerebral cortex 4 83.60 Quite High
opioid receptor 2 82.56 Quite High
Disease Link Frequency Relevance Heat
Death 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opiate drugs (and specifically the delta-agonists) could promote survival signals in the brain through inhibition of FADD, which in turn is dependent on the activation of the antiapoptotic ERK1/2 signaling pathway.
Positive_regulation (dependent) of Negative_regulation (inhibition) of FADD in brain associated with agonist and opiate
1) Confidence 0.46 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.07 Pain Relevance 0.77
In morphine- and SNC-80-tolerant rats, antagonist-precipitated (2 h) or spontaneous withdrawal (24-48 h) induced a new and sustained inhibition of FADD (13-50%).
Positive_regulation (induced) of Negative_regulation (inhibition) of FADD associated with antagonist, withdrawal and morphine
2) Confidence 0.40 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.21 Pain Relevance 1.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox