INT133607

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.41
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fadd) protein complex (Fadd) cytoplasm (Fadd)
Anatomy Link Frequency
corpus striatum 1
brain 1
Fadd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 10 100.00 Very High Very High Very High
agonist 12 99.40 Very High Very High Very High
cerebral cortex 4 98.04 Very High Very High Very High
Delta opioid receptors 2 95.36 Very High Very High Very High
tolerance 2 85.36 High High
addiction 2 84.80 Quite High
Morphine 6 82.32 Quite High
withdrawal 2 81.72 Quite High
antagonist 2 79.92 Quite High
opioid receptor 2 75.20 Quite High
Disease Link Frequency Relevance Heat
Death 6 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with SL 327 (a selective MEK1/2 inhibitor that blocks ERK activation) fully prevented the reduction of FADD content induced by SNC-80 in the cerebral cortex (43%) and corpus striatum (29%), demonstrating the direct involvement of ERK1/2 signaling in the regulation of FADD by the opiate agonist.
Regulation (regulation) of FADD in corpus striatum associated with agonist, opiate and cerebral cortex
1) Confidence 0.60 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.13 Pain Relevance 1.10
Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
Regulation (Effects) of FADD in brain associated with opiate and death
2) Confidence 0.44 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 16482086 Disease Relevance 0.28 Pain Relevance 0.94

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox