INT13362

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.79
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 2
plasma cells 1
cerebral cortex 1
medial 1
NFKBIL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 6 100.00 Very High Very High Very High
spinothalamic tract 4 100.00 Very High Very High Very High
MU agonist 1 100.00 Very High Very High Very High
cerebral cortex 3 99.60 Very High Very High Very High
Opioid 11 98.88 Very High Very High Very High
Immobilon 1 97.64 Very High Very High Very High
Kappa opioid receptor 9 96.52 Very High Very High Very High
Analgesic 10 96.20 Very High Very High Very High
Spinal cord 4 95.80 Very High Very High Very High
antagonist 7 94.72 High High
Disease Link Frequency Relevance Heat
Hyperphagia 9 99.88 Very High Very High Very High
Injury 9 97.08 Very High Very High Very High
Brain Injury 6 95.56 Very High Very High Very High
Cancer 15 94.96 High High
Persistent Vegetative State 63 92.44 High High
Death 24 90.80 High High
Apoptosis 6 90.04 High High
Epstein-barr Virus 5 88.16 High High
Sprains And Strains 3 86.12 High High
Skin Cancer 1 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The different distribution pattern of N2-N4 from conventional somatosensory-evoked potential suggested a different projection of LST from the medial lemniscus system.
Gene_expression (projection) of LST in medial associated with spinothalamic tract
1) Confidence 0.59 Published 1985 Journal Appl Neurophysiol Section Abstract Doc Link 3017209 Disease Relevance 0 Pain Relevance 0.17
Furthermore, the patient never expressed any explicit wishes regarding withdrawing LST in situations such as this.
Gene_expression (withdrawing) of LST
2) Confidence 0.56 Published 2004 Journal Crit Care Section Body Doc Link PMC420027 Disease Relevance 0.91 Pain Relevance 0.09
This conflict forces several issues: what level of evidence is required to justify removal of LST, which standard of surrogacy should be applied, and how ought QoL and the preservation of life be balanced?
Gene_expression (applied) of LST
3) Confidence 0.56 Published 2004 Journal Crit Care Section Body Doc Link PMC420027 Disease Relevance 0 Pain Relevance 0
These results indicate that kappa 1 and Kappa 2 opioid receptors exist in human cerebral cortex with different ligand binding profiles.
Gene_expression (exist) of kappa 1 in cerebral cortex associated with opioid receptor and cerebral cortex
4) Confidence 0.54 Published 1996 Journal Life Sci. Section Abstract Doc Link 8632704 Disease Relevance 0 Pain Relevance 0.43
The Hospital Authority has produced detailed guidelines on LST in the terminally ill [2].
Gene_expression (produced) of LST
5) Confidence 0.50 Published 2004 Journal Crit Care Section Body Doc Link PMC420027 Disease Relevance 0.09 Pain Relevance 0.03
Nuclear NF-kappaB and cytoplasmic IkappaB protein levels were determined by electrophoretic mobility shift assay and Western blot, respectively.
Gene_expression (levels) of IkappaB protein
6) Confidence 0.13 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.87 Pain Relevance 0.15
Although the levels of mu, kappa 1 and kappa 3 binding in whole brain homogenates did vary somewhat, they did not correlate with analgesic sensitivity.
Gene_expression (levels) of kappa 1 in brain associated with analgesic
7) Confidence 0.10 Published 1991 Journal Brain Res. Section Abstract Doc Link 1667610 Disease Relevance 0.32 Pain Relevance 0.97
Kappa 1 (kappa) and kappa 2 (benzomorphan) binding sites were individually detected by the overall labeling of opioid binding sites with [3H]-etorphine followed by the elimination of binding to particular sites by the use of appropriate selective unlabelled ligands.
Gene_expression (detected) of Kappa 1 associated with opioid and immobilon
8) Confidence 0.04 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6099476 Disease Relevance 0 Pain Relevance 0.35
Our results suggest that the cloned kappa and mu receptors have pharmacological characteristics similar to those of the endogenously expressed kappa 1 and mu receptors, respectively.
Gene_expression (expressed) of kappa 1
9) Confidence 0.02 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 8114680 Disease Relevance 0.08 Pain Relevance 0.62
The neoplastic plasma cells were monoclonal for Ig G and kappa light chain (Fig. 1E), and negative for lambda light chain (Fig. 1F).
Neg (negative) Gene_expression (monoclonal) of kappa light chain in plasma cells
10) Confidence 0.01 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.79 Pain Relevance 0
In +/- mice there was a decrease in [3H]CI-977 binding of approximately 50% whilst no kappa1-receptors could be detected in any brain region of homozygous animals confirming the successful disruption of the KOR gene.
Gene_expression (detected) of kappa1 in brain associated with kappa opioid receptor
11) Confidence 0.00 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082819 Disease Relevance 0.22 Pain Relevance 0.39
In contrast, DPDPE failed to alter 2DG-induced hyperphagia, and kappa1 and kappa3 opioid agonists each produced small, but significant increases in 2DG-induced hyperphagia.
Gene_expression (produced) of kappa1 associated with hyperphagia and mu agonist
12) Confidence 0.00 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077569 Disease Relevance 0.51 Pain Relevance 0.79

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